Nephrotoxicity Assay related Services
Creative Biolabs is a professional contract research organization (CRO) that conducts extensive research to gather specific details on renal toxicity mechanisms to deliver cutting-edge assays for drug discovery and research.
Necessity of Nephrotoxicity Assessment
Nephrotoxicity, also known as renal toxicity, is a prevalent cause of drug failure in the process of new drug development. The FDA recommends conducting in vitro nephrotoxicity assays on new drugs and biologics prior to testing them in vivo using animal models. Additional regulatory guidance from the FDA and EMA suggests in vitro nephrotoxicity models can detect early markers of nephrotoxicity more accurately.
To meet the increasing demands of nephrotoxicity evaluation, Creative Biolabs builds a team of experienced experts who can assist our clients with research design, experimental execution, and data analysis during the early stages of drug discovery. To reduce expenses and shorten research timeframes associated with novel drug development, we offer the following services for assessing nephrotoxicity:
PETC Model Assay
- Renal proximal tubular epithelial cells (PTEC) are the primary targets of nephrotoxic drugs and chemicals because they are responsible for glomerular reabsorption of altered solutes and excretion of waste products, xenobiotics, and their metabolites. Our recently created conditionally immortalized renal proximal tubule epithelial cells (iNPTEC) have proximal renal tubule features and express the most pertinent renal drug transporters. Our iNPTEC offers a precise model for evaluating nephrotoxicity in vitro and is incredibly sensitive and specific.
Pre-clinical Toxicology and DDl Services
- Preclinical toxicology studies are a crucial step in determining whether a drug can enter clinical trials, as they provide valuable information on possible safety and toxicity. It is critical to assess the drug-drug interactions (DDIs) of potential novel drugs. The FDA and EMEA advocate testing prospective DDls in vitro, which reveals the influence of different clearance pathways and leads to better candidate drugs entering clinical trials.
Drug-induced Renal Toxicity Assay
- For effective prevention of drug-induced nephrotoxicity, innovative biomarkers for diagnosing kidney impairment early and more accurately must be discovered and developed. Biomarkers contribute significantly to new drugs being developed by facilitating the drug toxicity evaluation process. Early detection of medication nephrotoxicity in vitro can assist reduce expenses associated with new drug safety assessments. We have developed a variety of cell-based assays, non-cell-based assays, and biomarkers.
You are able to easily reach a Creative Biolabs expert or our Customer Service team. Contact us with questions or to discuss your specific discovery challenges.
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