NeuroMab™ Anti-TREM2 Antibody(NRP-0422-P806)
A functional antibody raised against Human, Mouse TREM2.
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse
- Applications:
- FC; ELISA; Block; Inhib; In Vitro; In Vivo; Agonist
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryDescription
Immunogen
Species Reactivity
Clonality
Host Species
Applications
Relevant Diseases
Formulation
Preservatives
Concentration
Purification
Purity
Endotoxin Level
Low Endotoxin < 1 EU/mg
Shipping
Storage
Research Use Only
Figure 1 Anti-TREM2 antibody binds to TREM2 on the cell surface.
Anti-TREM2 antibody surface binding dose response in hTREM2-HEK cells. Binding of anti-TREM2 antibodies was titrated to HEK cells expressing human TREM2. Antibody binding was detected with a secondary anti-mouse multiplexed antibody conjugated to APC. RS9.F6 and RS9.F10 demonstrate binding to human TREM2 cells with an EC50 of less than 2 nM.
Figure 2 Binding of anti-TREM2 antibodies to primary human macrophages.
Binding of anti-TREM2 antibodies to primary human monocyte-derived macrophages was screened by FACS. Antibody binding was detected with a secondary anti-mouse multiplexed antibody conjugated to APC. Gray line = secondary antibody alone. Black line = TREM2 antibody.
Figure 3 Anti-TREM2 antibody activates P-Syk.
Determining the P-Syk Activating Dose Response of Anti-TREM2 Antibodies. Anti-TREM2 antibodies were dose titrated to HEK cells expressing human TREM2, and pSyk induction was calculated as a buffer control fold. EC50 values show the nM potency and fold induction of pSyk for each antibody.
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