Mouse Anti-Human S100A8/A9 Heterodimer Monoclonal Antibody (CBP3701)

Product Overview

Description

S100A8/A9, also known as Calprotectin, is a heterodimeric protein that belongs to the family of low molecular weight, calcium binding S100 proteins with two EF-hand calcium binding domains. S100A8/A9 is elevated in blood and other body fluids in many pathological conditions including rheumatoid arthritis, inflammatory bowel diseases, viral or microbial infections, and tumors. S100A8/A9 is identified as an endogenous activator of TLR4 and is involved in promoting the inflammatory response in infections.

Immunogen

Recombinant human A100A8/A9

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP3701

Applications

Block

Application Notes

Block (2-8 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

0.2 µm filtered in PBS, pH 7.2, containing no preservative.

Concentration

Batch Dependent

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Endotoxin level is <0.01 EU/µg of the protein (<0.001 ng/µg of the protein) as determined by the LAL test.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

S100A8/A9 Heterodimer

Official Name

S100A8/A9 Heterodimer

Full Name

S100A8/A9 Heterodimer

Alternative Names

S100A8/A9 Heterodimer

References

1. Sampson B, et al. 2002. Lancet. 360:1742-5.
2. Vogl T, et al. 2007. Nat. Med. 13:1042-9.
3. Semprini S, et al. 2002. Hum. Genet. 111:310-3.
4. Corbin BD, et al. 2008. Science 319:962-5.
5. Gopal R, et al. 2013. Am. J. Respir. Crit. Care Med. 188:1137-46.
6. Siegenthaler G, et al. 1997. J. Biol. Chem. 14:9371-7.
7. Ryckman C, et al. 2003. J. Immunol. 170:3233-42.
8. Ryu MJ, et al. 2012. J. Biol. Chem. 287:22948-58.
9. Ehrchen JM, et al. 2009. J. Leuko. Biol. 3:557-66.
10. Wang J, et al. 2015. FASEB J. 29(1):250-62.
11. Champaiboon C, et al. 2009. J. Biol. Chem. 284:7078.

Publications