Mouse Anti-Human Neurturin Monoclonal Antibody (CBP4018)

Product Overview

Description

Neurturin belongs to the GDNF family of ligands, which consists of 4 members: GDNF, Neurturin, Artemin, and Persephin. Neurturin functions as a ligand for the GFRα2 and RET complex. Neurturin is a potent neurotrophic factor that can promote the survival of numerous neuronal populations. Neurturin is synthesized as a precursor protein that is cleaved to release the carboxy-terminal domain. The carboxy-terminal domain contains seven conserved cysteine residues that are necessary for the formation of the cysteine-knot and the single interchain disulfide bond. The functional form of human Neurturin is a disulfide-linked homodimer of the carboxy-terminal 102 amino acid residues.

Immunogen

Recombinant human Neurturin

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP4018

Applications

Block

Application Notes

Block (0.2-5 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

0.2 µm filtered in PBS, pH 7.2, containing no preservative.

Concentration

Batch Dependent

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Endotoxin level is <0.01 EU/µg of the protein (<0.001 ng/µg of the protein) as determined by the LAL test.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Neurturin

Official Name

NRTN

Full Name

Neurturin

Alternative Names

NTN

Gene ID

4902(Human); 18188(Mouse); 84423(Rat)

Uniprot ID

Q99748(Human); P97463(Mouse)

References

1. Kotzbauer PT, et al. 1996. Nature 6608:467-70.
2. Doray B, et al. 1998. Hum. Mol. Genet. 7:1449-52.
3. Milbrandt J, et al. 1998. Neuron 20:245-53.
4. Baloh RH, et al. 1998. Neuron. 21:1291-302.
5. Sariola H, Saarma M. 2003. 116:3855-3862.
6. Ruiz-Ferrer M, et al. 2011. J. Mol. Med. (Berl) 5:471-80.
7. Lindholm D, et al. 2016. Cell Mol. Life Sci. 7:1365-79.

Publications