Ligand-Gated Ion Channel Related Research Reagents

Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion channel proteins allowing ions to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.

Mechanism

When a presynaptic neuron is excited, it releases neurotransmitters from the vesicle to the synaptic cleft. The neurotransmitter then binds to the receptors on the postsynaptic neuron. If these receptors are ligand-gated ion channels, the conformational changes that occur will open the ion channels, causing ions to flow through the cell membrane. In turn, this leads to depolarization (for excitatory receptor responses) or hyperpolarization (for suppressing responses).

Ligand-Gated Ion-channel Proteins

These receptor proteins usually consist of at least two different domains: a transmembrane domain including an ion pore and an extracellular domain including a ligand-binding site (allergic binding site). The function of this receptor located at the synapse is to directly and very quickly convert the chemical signal of the neurotransmitter released before the synapse into a post-synaptic electrical signal.

Generally, LICs are divided into three super-families that lack evolutionary relationships: cys-loop receptors, ionotropic glutamate receptors and ATP-gated channels.

Super-families	Subfamilies	Class
Cys-loop receptors	Cationic cys-loop receptors	Serotonin (5-HT); Nicotinic acetylcholine (nAChR); Zinc-activated ion channel (ZAC)
Cys-loop receptors	Anionic cys-loop receptors	GABAA, Glycine (GlyR)
Ionotropic glutamate receptors		AMPA, Kainate, NMDA
ATP-gated channels		P2X, PIP2

The research of ligand-gated ion channels requires a series of scientific research products. Creative Biolabs has been devoted to the research and development of the most advanced reagents to assist ion channel research. Our product portfolio covers a complete list of ion-channel proteins activators and blockers, monoclonal antibodies, labeled antibodies, proteins and assay kits.

Please browse the options to take a deeper look at the tools for your research needs.

For Research Use Only. Not For Clinical Use.

Target

CHRND

AIP

CHRNA3

TRPM4

CHRNA6

CLCNKB

GABARAPL2

DDR2

Syntrophin

Rapsyn

ClC-5

mGluR1

CHRNE

GRIN2A

CHRNA1

GABARAPL1

CHRNB4

GABA A Receptor Alpha 5

SLC31A1

GRIA2

GRASP1

NR3B

GJB1

KA1

ClC-2

GluN2C

GABARAPL3

GABARAP

Glutamate Receptor 1

GRIN1

CHRNA4

GABRE

Ligand-Gated Ion Channel Related Research Reagents

Mechanism

Ligand-Gated Ion-channel Proteins

Target

The Spectrum of Stem Cell-Based Neuronal Models and Their Fit for Purpose