3D Disease Modeling Services

Progress in biomedical research and therapeutic discovery is often constrained by preclinical models that fail to faithfully recapitulate the intricate pathophysiology of human disease. While foundational, two-dimensional (2D) cultures cannot reproduce the complex cytoarchitecture and intercellular signaling of living tissue, and animal models frequently present translational hurdles due to significant species-specific differences in genetics and physiology. This gap underscores the urgent need for more predictive, human-relevant research platforms.

Creative Biolabs is leading the paradigm shift toward more powerful in vitro systems with our Advanced 3D Disease Modeling Services. By harnessing the remarkable self-organizing capacity of human induced pluripotent stem cells (hiPSCs), we build sophisticated organoid and assembloid platforms that mirror the developmental processes and pathological hallmarks of human disease with exceptional fidelity. Our models provide a robust, scalable, and human-centric approach to accelerate your research from fundamental mechanistic discovery to the validation of novel therapeutic candidates.

Our Comprehensive 3D Disease Modeling Portfolio

We have developed a broad spectrum of validated, disease-specific organoid models. Our expertise allows you to investigate complex pathologies across a wide range of therapeutic areas. Find your area of interest below to learn how our advanced platforms can empower your research.

• Brain Tumor Organoid Modeling Service
  Investigate the invasive dynamics and therapeutic resistance of human brain tumors in a model that preserves the native tumor microenvironment and genomic landscape.
• Neurodegeneration Organoid Modeling Service
  Model the signature proteinopathies and cell-type-specific vulnerabilities of Alzheimer's, Parkinson's, and other neurodegenerative conditions in anatomically specific organoids.
• Neurodevelopment Organoid Modeling Service
  Utilize functional assembloids to dissect the core processes of human brain development, from neuronal migration to the formation of complex neural circuits.
• Neuropsychiatric Disorder Organoid Modeling Service
  Bridge the gap between genetic risk and circuit dysfunction by modeling conditions like schizophrenia and autism in human-specific assembloid systems.
• Cerebrovascular Disorder Organoid Modeling Service
  Reconstruct the human neurovascular unit with our vascularized organoids to study blood-brain barrier integrity, stroke pathology, and drug transport.
• Headache Disorder Organoid Modeling Service
  Build and interrogate the key circuits of the trigeminovascular system to investigate the cellular basis of migraine, central sensitization, and pain processing.
• Neuroinfectious Disorder Organoid Modeling Service
  Model the complete host-pathogen lifecycle with our neuro-immune organoids, essential for studying viral tropism, neuroinflammation, and antiviral therapeutics.
• Retinopathies Organoid Modeling Service
  Recapitulate the exquisitely laminated structure of the human neural retina to investigate inherited diseases, glaucoma, and novel cell or gene therapies.
• Accelerated Aging & Senescence Organoid Modeling Service
  Investigate the hallmarks of cellular senescence and neuro-inflammaging in the brain to screen for novel senolytic and senomorphic compounds.

Our Workflow

Validate Your Hypothesis in a Human-Relevant System

Partner with Creative Biolabs to leverage the predictive power of 3D organoid technology. Contact our specialists to design a study that will deliver clear, actionable, and transformative insights for your therapeutic program.