Tibial Nerve Injury (TNI) Model Development Service

Are you currently facing long drug development cycles and challenges in creating reproducible preclinical models? Our tibial nerve injury (TNI) models development service helps you accelerate drug discovery and obtain robust, reproducible preclinical data through advanced, standardized surgical techniques and a comprehensive multi-modal assessment platform. Our expertise minimizes experimental variability, allowing your team to focus on the science and advance your therapeutic candidates with confidence.

Peripheral nerve injuries (PNI) are a major cause of disability worldwide, driving a critical need for new therapeutic interventions. Preclinical research relies on animal models to study the mechanisms of injury and evaluate potential treatments. However, the lack of standardized protocols in these models often leads to inconsistent and irreproducible data. Our TNI models development service offers a solution by providing a highly consistent, professionally executed platform for your research.

How Our TNI Models Development Service Can Assist Your Project

At Creative Biolabs, we understand that the success of your preclinical program hinges on the quality and reliability of your animal models. Our TNI models development service provides a validated and highly consistent platform to support your research into nerve regeneration, neuropathic pain, and muscle atrophy. We eliminate the variability associated with in-house model development by delivering precisely executed surgical procedures and a comprehensive suite of objective endpoints. Our core deliverables include the establishment of robust injury models that mimic human conditions, quantitative data on therapeutic efficacy, and a clear path to understanding the mechanism of action of your compound. Our capabilities provide you with the high-quality, translatable data required to confidently move your program forward.

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Workflow

Our standardized and meticulously detailed workflow is designed for clarity and efficiency, ensuring a seamless experience and predictable outcomes for your project.

• Required Starting Materials: To initiate a project, clients typically provide a detailed study plan or protocol, including the therapeutic agent to be tested and its administration schedule, as well as any specific endpoints or assays of interest. We can also work with you to design a protocol from scratch.

• Final Deliverables: Upon project completion, you will receive a comprehensive final report detailing all methods, raw data, statistical analyses, and a clear summary of the findings. We also provide histology slides with annotated images and a complete dataset from all behavioral and electrophysiological assessments.
• Estimated Timeframe: The typical timeframe for a TNI models study ranges from 6 to 12 weeks, depending on the complexity of the project, the number of experimental groups, and the duration required for therapeutic evaluation.

Why Choose Us?

CBL stands apart as a partner in preclinical research due to our unwavering commitment to scientific rigor, consistency, and a comprehensive approach to data collection. Our models are executed with precision, ensuring minimal variability between animals and studies. We go beyond a single endpoint, providing a multi-modal assessment that includes behavioral, electrophysiological, and histological data to give you a complete picture of therapeutic efficacy. Published Data demonstrates that our standardized approach yields highly reproducible results, a critical factor for successful translation to the clinic.

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Customer Reviews:

"Using CBL's TNI models development service has significantly improved the reproducibility of our neuropathic pain studies. We were struggling with inconsistent pain behaviors in our in-house models, but their standardized approach gave us a reliable platform to test our novel analgesic. The detailed electrophysiology data was particularly valuable." – Published 2025, J***e M.

"The expertise of the CBL team was a game-changer for our nerve regeneration project. Their ability to precisely execute the TNI crush model and provide a comprehensive morphometric analysis of axonal density allowed us to quantitatively prove our therapeutic's efficacy. It saved us a tremendous amount of time and resources." – Published 2025, A***n P.

"We relied on CBL for our study on denervation-induced muscle atrophy. Their TNI transection model provided a perfect platform for our work. The quality of the muscle histology they delivered, showing a clear reduction in atrophy in our treated group, was a tangible benefit that supported our hypothesis and moved our research forward." – Published 2025, S***n W.

Tibial Nerve Injury (TNI) Models

The tibial nerve is a critical peripheral nerve, making it a powerful target for preclinical studies. CBL offers a range of scientifically validated models to address various research questions.

• Tibial Nerve Transection: This model is the gold standard for studying severe denervation and its long-term consequences, such as skeletal muscle atrophy and fibrosis. It is also an excellent tool for investigating complex pain syndromes, including Sympathetically Independent Pain (SIP). Our precision surgery ensures complete nerve severance, leading to a consistent and measurable outcome.
• Tibial Nerve Crush Injury: This model simulates a more common clinical scenario where the nerve's structural continuity is preserved but its function is compromised. It is ideal for evaluating therapies that aim to accelerate the natural regenerative process.
• Distal Tibial Injury (DTI) Model: Our DTI model is specifically designed to replicate nerve injuries in the distal extremities, which are highly prevalent in humans. This model provides a clinically relevant platform for testing treatments for conditions affecting the hands and feet.

What We Can Offer

• One-stop service for preclinical models from initial consultation to final data delivery, including surgical model development, in-life dosing, and comprehensive end-of-study assessments.
• Customized model design to align with your specific research objectives, including variations in injury type (transection, crush, DTI), animal species (rat, mouse), and study duration.
• A full suite of high-quality control tools to quantify and evaluate therapeutic efficacy, including gold-standard behavioral tests, advanced electrophysiology, and detailed histology.
• Robust documentation and quality assurance of all experimental procedures and animal care, ensuring the integrity and reproducibility of your study data.
• Flexible and scalable project capabilities, allowing us to support both small-scale pilot studies and larger, more complex efficacy programs.
• An unwavering commitment to ethical animal care and strict aseptic surgical techniques, guaranteeing the well-being of the animals and the quality of the scientific outcomes.

Related Services

To further support your research, CBL offers a suite of complementary services that can be integrated with our TNI models.

• Acute Pain Models
• Inflammatory Pain Models
• Biomarker Development & Validation
• Neuroinflammation Studies

To learn more about our services or to discuss how our team can support your specific project, please reach out to us. We look forward to partnering with you.

Contact Our Team for More Information and to Discuss Your Project.