Paclitaxel induced Neuropathy Pain Model Development Service

Are you currently facing long drug development cycles or difficulty in creating clinically relevant preclinical models for neuropathic pain? Our paclitaxel-induced neuropathy pain model development service helps you accelerate drug discovery and obtain high-quality, translatable preclinical data through advanced multi-cycle dosing regimens, comprehensive behavioral phenotyping, and mechanistic elucidation.

Paclitaxel-induced neuropathy (PIN) is a severe, dose-limiting side effect of paclitaxel chemotherapy, affecting up to 98% of patients. It causes chronic pain and sensory dysfunction, significantly impacting quality of life and often leading to treatment discontinuation. Despite its prevalence, effective therapies are lacking. Preclinical models are crucial for discovering new analgesics and neuroprotective agents. Creative Biolabs' service provides advanced, clinically relevant models to bridge the translational gap, accelerating the development of much-needed solutions for this unmet medical need.

How Our PIN Pain Model Development Service Can Assist Your Project?

At CBL, we provide robust, validated PIN models that deliver comprehensive data packages and crucial mechanistic insights, empowering your drug discovery efforts. Our service is designed to generate highly predictive preclinical data, enabling you to make informed decisions and advance your most promising therapeutic candidates with confidence. We offer a tailored approach to ensure the model precisely addresses your research objectives, from early-stage screening to in-depth mechanistic studies.

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Workflow

Our streamlined workflow ensures efficiency, reproducibility, and scientific rigor at every stage of your project. This comprehensive process is designed for clarity and can be visualized as a flowchart, outlining each critical step:

• Required Starting Materials:

To initiate the service, clients typically provide:

1. Project Scope and Research Questions: A clear outline of your therapeutic goals, target molecules, and specific research questions you aim to answer (e.g., efficacy of a novel analgesic, comparison with a standard of care, mechanistic insights into neuroprotection).
2. Test Compound Information: Details regarding your compound(s) including chemical structure (if applicable), proposed mechanism of action, solubility, stability, and any existing in vitro or in vivo preliminary data.
3. Specific Assay Preferences: Any particular behavioral assays, histological stains, or molecular analyses you wish to prioritize or integrate into the study design.

• Final Deliverables:

Upon completion of the service, you will receive:

1. Comprehensive Study Report: A detailed document encompassing all experimental procedures, raw data, statistical analyses, and scientific conclusions.
2. Raw Data Files: Complete raw data sets from all behavioral and mechanistic assays for your independent analysis.
3. Mechanistic Analysis Data: Specific data from molecular and cellular assays, including images, graphs, and quantitative measurements.

• Estimated Timeframe:

The typical timeframe for this service ranges from 8 to 16 weeks, depending on the complexity of the study design, the number of compounds to be tested, and the depth of mechanistic analysis requested. Our team will provide a precise timeline during the initial consultation.

Why Choose Us?

Choosing CBL for your PIN pain model development service means partnering with a leader in preclinical pain research. Our unique advantages are built on two decades of specialized expertise, ensuring your projects are executed with unparalleled scientific rigor and a focus on translational success.

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Customer Reviews

"Exceptional Model Fidelity. Using CBL's PIN pain model development service in our research has significantly improved our ability to identify truly effective compounds, as their models accurately reflect the chronic nature of human PIN, unlike simpler models we've used previously. The detailed behavioral and mechanistic data provided unparalleled insights into our compound's action. Their team's guidance on experimental design was invaluable, ensuring optimal data quality and interpretability." May 2025, Dr. Js Mn.

"Accelerated Preclinical Validation. CBL's service facilitated a rapid and robust preclinical validation of our lead candidate for neuropathic pain. Their comprehensive workflow, from model induction to detailed mechanistic analysis, provided a complete data package that significantly strengthened our internal decision-making process. The consistent reproducibility of their model allowed us to confidently move forward with our most promising candidates, saving us considerable time and resources." April 2025, Dr. Sh Kr.

"Unmatched Scientific Collaboration. The collaborative approach of CBL's team was a game-changer for our project. They seamlessly integrated their expertise in PIN modeling with our specific research questions, providing tailored solutions and proactive communication throughout the entire process. Their attention to detail in behavioral phenotyping, particularly the ethological assays, offered a more holistic view of pain alleviation than we anticipated. The data quality and their scientific support were truly outstanding." June 2025, Dr. La Pz

Paclitaxel-Induced Neuropathy Pain Model

Traditional preclinical models, often employing single-cycle paclitaxel administration, frequently fail to capture the chronic, persistent nature of PIN observed in patients receiving multiple chemotherapy cycles. This translational gap is a significant hurdle in drug development. CBL's PIN pain model addresses these limitations by utilizing clinically relevant multi-cycle paclitaxel administration protocols in rodent models (e.g., male Sprague-Dawley rats and C57BL/6J mice). This approach generates persistent, long-lasting neuropathic pain phenotypes that closely mirror the human condition.

Our models are rigorously characterized through comprehensive behavioral phenotyping, including tactile allodynia (demonstrated by hypersensitivity to touch and alleviation with gabapentin), cold hypersensitivity, and advanced ethological assays like spontaneous burrowing and nocturnal wheel running. These methods allow for the capture of both evoked and ongoing pain-like behaviors, providing a more holistic and clinically relevant assessment of analgesic efficacy. Furthermore, we offer detailed mechanistic elucidation capabilities to investigate the underlying molecular and cellular pathways, including the role of SARM1 in axonal self-destruction, providing deeper insights into drug action and potential therapeutic targets.

What We Can Offer

At CBL, we are committed to providing you with a superior partnership for your PIN pain model development service needs. Our offerings are meticulously designed to deliver precision, efficiency, and actionable insights, all tailored to your unique research goals.

• Clinically Relevant PIN Models: We develop and validate models that accurately mimic the chronic and persistent nature of human paclitaxel-induced neuropathy, utilizing multi-cycle dosing regimens in appropriate animal species (e.g., rats, mice) to ensure high translational value.
• Comprehensive Behavioral Phenotyping: Beyond standard pain assessments, we employ advanced ethological assays (e.g., burrowing, wheel running) to capture ongoing pain-like behaviors, providing a more complete and clinically relevant picture of analgesic efficacy.
• Deep Mechanistic Elucidation: Our capabilities extend to detailed molecular and cellular analyses of neural tissues, including assessment of neuroinflammation, mitochondrial dysfunction, ion channel activity, and axonal integrity, to uncover the precise mechanisms of your compound's action.
• Customized Study Design & Execution: We offer highly flexible and customized study designs, from optimizing paclitaxel dosing and animal strains to integrating specific readouts and endpoints, ensuring the model perfectly aligns with your project's unique requirements.
• Expert Scientific Consultation: Benefit from the guidance of our seasoned biology specialists with over 20 years of experience, ensuring robust experimental design, insightful data interpretation, and strategic project advancement.
• High-Quality, Reproducible Data: Our rigorous adherence to best practices, stringent quality control, and comprehensive reporting (including ARRIVE guidelines) guarantees the generation of reliable, reproducible, and publication-ready data.
• Accelerated Drug Discovery Timelines: By providing well-characterized and highly predictive models, we help you streamline your preclinical pipeline, reduce research costs, and accelerate the progression of promising drug candidates toward clinical development.

Related Services

To further support your drug discovery and development efforts, CBL offers a suite of complementary services that can be integrated with our PIN pain model development service:

• Acute Pain Models
• Inflammatory Pain Models
• Biomarker Development & Validation
• Neuroinflammation Studies

Ready to discuss your next project or learn more about how our PIN pain model development service can benefit your research? Our expert team is here to answer your questions and provide tailored solutions.

Contact Our Team for More Information and to Discuss Your Project.