Ligand-Gated Ion Channel Related Research Reagents

Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion channel proteins allowing ions to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.

Mechanism

When a presynaptic neuron is excited, it releases neurotransmitters from the vesicle to the synaptic cleft. The neurotransmitter then binds to the receptors on the postsynaptic neuron. If these receptors are ligand-gated ion channels, the conformational changes that occur will open the ion channels, causing ions to flow through the cell membrane. In turn, this leads to depolarization (for excitatory receptor responses) or hyperpolarization (for suppressing responses).

Ligand-Gated Ion-channel Proteins

These receptor proteins usually consist of at least two different domains: a transmembrane domain including an ion pore and an extracellular domain including a ligand-binding site (allergic binding site). The function of this receptor located at the synapse is to directly and very quickly convert the chemical signal of the neurotransmitter released before the synapse into a post-synaptic electrical signal.

Generally, LICs are divided into three super-families that lack evolutionary relationships: cys-loop receptors, ionotropic glutamate receptors and ATP-gated channels.

Super-families	Subfamilies	Class
Cys-loop receptors	Cationic cys-loop receptors	Serotonin (5-HT); Nicotinic acetylcholine (nAChR); Zinc-activated ion channel (ZAC)
Cys-loop receptors	Anionic cys-loop receptors	GABAA, Glycine (GlyR)
Ionotropic glutamate receptors		AMPA, Kainate, NMDA
ATP-gated channels		P2X, PIP2

The research of ligand-gated ion channels requires a series of scientific research products. Creative Biolabs has been devoted to the research and development of the most advanced reagents to assist ion channel research. Our product portfolio covers a complete list of ion-channel proteins activators and blockers, monoclonal antibodies, labeled antibodies, proteins and assay kits.

Please browse the options to take a deeper look at the tools for your research needs.

For Research Use Only. Not For Clinical Use.

Target

HCN2

GABARAPL3

CLCNKB

GRIA2

GJB1

GRIN1

KA1

CHRNA3

GABA A Receptor Alpha 5

CHRNB4

GRIN2A

CHRNA6

Syntrophin

CHRND

GABRE

GluN2C

GABARAPL1

DDR2

GABARAP

CLC3

mGluR1

Glutamate Receptor 1

GRASP1

SLC31A1

ClC-2

MLC1

GABARAPL2

CHRNA4

LYNX1

NR3B

Rapsyn

CHRNE