Alzheimer's Disease Related Research Tools

Alzheimer's disease (AD) is the most common form of dementia, a complex neurodegenerative brain disorder characterized by the progressive impairment of cognitive functions, particularly memory, thinking, language, mood, and behavioral issues.

AD is biologically defined by the presence of β-amyloid (Abeta) -containing plaques and tau-containing neurofibrillary tangles. Abeta plaques are formed by the aggregation of beta-amyloid peptides, which are fragments of a larger protein called amyloid precursor protein (APP).

Tau tangles, on the other hand, result from the abnormal phosphorylation and aggregation of tau protein, which is normally involved in maintaining the stability of microtubules within neurons. In Alzheimer's disease, tau protein forms twisted filaments called neurofibrillary tangles.

The accumulation of beta-amyloid plaques and tau tangles initiates a cascade of events that contribute to the progressive neurodegeneration observed in AD. This includes the activation of immune cells (microglia), inflammation, impairment of synaptic connections, and disruption of various signaling pathways in the brain.

As the disease progresses, affected individuals experience a decline in cognitive abilities, memory loss, disorientation, language difficulties, and changes in behavior and personality.

Biological Processes and Targets Related to Alzheimer's Disease

Biological processes	Targets
Amyloid-beta plaques formation	APP, Aβ, PSEN1, PSEN2, B2M, Gal-3, AICD, BACE1, RAGE, ADAM, ApoE4, NEP, IDE, GSK-3
Neurofibrillary tangle formation	Tau, NF-kB, TNF-α, ILs, Cdc42, GSK-3β, CDK5, TPK-1, MARK, MAPK, AMPK, Dyrk1A, p53, PAC1R, ERK, CREB, CaMKII
Neuroinflammation	TNF-α, TREM2, CD33, NF-κB, CD36, Calhm2, NLRP2, APOE, PGE2, IL-1, IL-2, IL-4, IL-1β, IL-6, IL-10, IFN-γ, TGF-β, SR-A, CR1, ABCA7, KMO, IFN-γ, P2X7R, TLR, CSF1R, miR-155, STAT3, CaSR, ABCA1, BACE1, Aqp4
Oxidative stress	NRF2, NADPH, PGC1α, miRNA-485, SIRT-1, PPAR-α
Mitochondrial dysfunction	PGC1α
Cholinergic insufficiency	AChE, BuChE, NGF
Autophagy dysfunction	PKA, Drp-1, Parkin, mTOR, AMPK, LOX
Neurovascular dysfunction	GLUT1, LRP1, P-gp, RAGE, CypA-MMP9
Synapse loss and alterations	NLRP3, RhoA, BDNF, PKCɛ, Jacob, NCAM, MAPK, ERK, NGF, ACSS2, CREB, NMDAR
Ferroptosis	NRF2, GPX4, GSS
Lipid dyshomeostasis	APOE, HMG-CoA, ACAT1
Genetic risk factor	APOE4, APP, PSEN1, PSEN2

Creative Biolabs offers a wide range of cutting-edge research products geared toward the investigation of biological processes underlying Alzheimer's disease. Our products including antibodies, cell lines, proteins & peptides, and assay kits, are among the bio-reagents keenly sought by neuroscience researchers.

For Research Use Only. Not For Clinical Use.

Target

ERAB

CD163

RAGE

Ferritin Light Chain

S100A8

KCNC4

AACT

Malondialdehyde

Acrolein

GAPDH

ADAM10

proCathepsin D

Alpha Synuclein

ERK1/ERK2

Marco

CYP46A1

EPHX2

Sigma1-Receptor

Urokinase

CD11b

PIN1

LRP1

Bax

MUC2

SYT1

OGT

pMAPT /pTAU

ITM2B

S100 Beta

SHC