Lumbar Disk Disease Related Research Tools

Lumbar disk disease (Herniated Disk), a major cause of lower back pain, is the drying out of the spongy interior matrix of an intervertebral disc in the spine. It is also known as lumbar spondylosis. Pain, loss of muscle strength and loss of touch sensation may occur in patients with lumbar disk disease. In severe cases, a herniated disc can produce a dysfunction of the nerve.

Lumbar disk disease is caused by a change in the structure of the normal disk. Most of the time, lumbar disk disease results from aging. However, an inheritable gene variation may cause increased susceptibility. Cartilage intermediate-layer protein (CILP) is a normal component of the disk tissue. The CILP variant is hypothesized to disrupt the normal building and maintenance of the cartilage. People with CILP mutant are 1.6 times more likely to develop the disease.

Creative Biolabs has a comprehensive list of bio-reagents involving in lumbar disk disease (herniated disk) research. The following is a part of our featured products that may be associated with your areas of interest.

Neural Cell Lines
Basal Media
Media Supplements
Specialty Media
Cell Differentiation Media
Cell Dyes
Neural Cell Culture Antibiotics

Assay Kits
Buffers & Solutions
Neural Antibodies
Recombinant Proteins
Cytokines
Growth Factors
Small Molecules

Toxins
Agonists
Antagonists
Animal Models
Tools & Devices

Creative Biolabs appreciates the critical roles that our products play in research efforts to further Lumbar disk disease (Herniated disk) diagnosis and treatment.

Pathways Related to Creative Biolabs Products of Lumbar Disk Disease (Herniated Disk)

Super pathways	Genes
ERK signaling	IL6, IL1B, IL1A, COL9A3, COL9A2, COL11A2
Phospholipase-C pathway	IL6, COL9A3, COL9A2, COL11A2, COL11A1
Focal adhesion	THBS2, COL9A3, COL9A2, COL11A2, COL11A1
Collagen chain trimerization	MMP9, COL9A3, COL9A2, COL11A2, COL11A1
Degradation of the extracellular matrix	MMP9, COL9A3, COL9A2, COL11A2, COL11A1, ASPN
T cell receptor signaling pathway	IL6, IL1B, IL1A, IFNG
IL-17 family signaling pathway	MMP9, IL6, IL1B, IFNG
Toll comparative pathway	IL6, IL1B, IL1A, IFNG

For Research Use Only. Not For Clinical Use.

Target

SHANK1

Gemin 3

Synapsin I

CRMP3

TNFR2

Cathepsin D

SNAP23

NEFM

Amyloid Beta

GLUD2

CT A

Netrin 1

DISC1

BK channel BETA2

SOD1

SETD2

SPOCK1

HOMER3

PHGDH

Myelin

Prickle

PRKAR2A

Zimp

Neurofilament L

SOX2

GFAP

Sarcoplasmic Reticulum

LRRK2

IL-1α

TRPM4

GSK3 Alpha