iPSC and iPSC-derived Cells

Induced pluripotent stem cells (iPSCs) are a type of stem cells that are generated from embryonic cells or adult somatic cells, such as mesenchymal stromal cells (MSCs), fibroblasts and peripheral blood mononuclear cells (PBMCs) through a process called reprogramming. This reprogramming involves introducing OCT4, SOX2, KLF4, and L-MYC genes by episomal plasmids or retroviral transduction that are essential for maintaining pluripotency. iPSCs have the remarkable ability to self-renew and develop into any type of somatic cell, making them valuable and powerful tools for disease modeling and drug discovery.

With a decade of expertise in the field, Creative Biolabs has built up advanced manufacturing capabilities for producing top-notch, functional iPSC and iPSC-derived cells with exceptional uniformity. If you are looking for iPSC-related cells, please feel free to contact us. We also provide made-to-order products with our lines or your lines.

Case Study

Microglia are immune cells found in the brain that help maintain the health and function of neural cells. Dysfunction in microglia has been linked to the development of neurodegenerative diseases, like Alzheimer's disease, where they may contribute to the progression of symptoms and cognitive decline.

We have optimized a culture protocol to generate single microglia from iPSCs, which specifically express Iba1, P2Y12, and TREM2, for modeling neurodegenerative and neuroinflammatory diseases.

Fig 1 Representative images of immunostaining of iPSC microglia after 24 days differentiation in monoculture. (Reich, 2021) Fig.1 Human iPSC-derived microglia stain positive for Iba1 (cyan), P2Y12 (yellow), and TREM2 (red).¹

Trending Products

We are proud to offer a catalog of ready-to-ship iPSC and iPSC-derived cells from healthy or diseased patients (Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, and Amyotrophic Lateral Sclerosis) to help explore the research of neuroscience, pain, and sensation.

Cat. No.	Product Name	Cat. No.	Product Name
NCL-2103-P85	Human iPSC Line (Episomal, PBMC-derived)	NCL-2105-P121-IX	Human iPS Cell Line (Alzheimer's Disease)
NCL-2105-P127-IX	Human iPS Cell Line (Parkinson's Disease)	NCL-2105-P126-IX	Human iPS Cell Line (Amyotrophic Lateral Sclerosis)
NCL-2105-P128-IX	Human iPS Cell Line (SOD1 mutation, A4V, HOM)	NCL200552ZP	iNeu™ Human Neural Stem Cell Line
NCL-2101-ZP09	iNeu™ Human Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 A246E)	NCL-2103-P80	iNeu™ Human Neural Progenitor Cells
NCL-7P030	iNeu™ Astrocytes	NCL-7P018	iNeu™ Microglia
NCL-7P031	iNeu™ Microglia AD APOE E4/E4	NCL-2103-P78	iNeu™ Human Cortical Neurons
NRZP-1122-ZP263	iNeu™ Human Striatal Neurons	NRP-0322-P2180	iNeu™ Human Peripheral Neurons
NCL-2105-P132-IX	iNeu™ Human Motor Neurons	NCL-2103-P62	iNeu™ Human Sensory Neurons
NCL-21P6-003	iNeu™ Human Midbrain Dopaminergic Neurons	NRZP-1122-ZP297	iNeu™ Human GABAergic Neurons
NRZP-1122-ZP345	iNeu™ Human Cholinergic Neurons	NCL-7P021	iNeu™ GlutaNeurons
NCL-2103-P63	iNeu™ Human Schwann Cells	NCL-2103-P70	iNeu™ Human Retinal Pigment Epithelial Cells
NCL-2103-P73	iNeu™ Human Keratinocytes	NRP-0322-P2185	iNeu™ Human Sebocytes

Reference

Reich, Marvin et al. "Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia." Front Immunol. 2021, 11:617860.

For Research Use Only. Not For Clinical Use.

Target

APOE

TREM2

MECP2

ABCA7

CD33

TDP43

SNCA