Microglia Marker Related Research Reagents
Microglia are resident macrophages in the central nervous system (CNS) and play an immune defense role. They exist in a static state in healthy CNS tissues, actively investigate the surrounding areas after being injured or infected, and can be quickly activated in response to environmental changes.
Once a threat is detected, the microglia will undergo morphological changes. Activated microglia are divided into two states, M1 and M2, based on their morphology. M1 microglia are the cells that initially respond to injury and cause proinflammatory responses. Cytokines, such as IFN-γ and TNF-α, as well as bacteria and cell debris, will polarize microglia to the M1 phenotype. M2 microglia are "alternatively" activated microglia, also recognized as anti-inflammatory microglia, that can promote the regression of neuroinflammation and stimulate tissue repair.
Fig.1 Schematic description of microglial activation and polarization in the central nervous system.
Summary of Microglia Markers Provided by Creative Biolabs
Steady-State Microglia Markers
Subcellular Localization | Markers | |
Cytoplasmic | AIF-1/Iba1 | |
Cell Surface |
CD11b/Integrin aM CD45 CX3CR1 F4/80/EMR1 FcγRI/CD64 FCRL4/FcRH4 |
M-CSF R/CD115 Mer P2Y12/P2RY12 Siglec-H TMEM119 |
Secreted | BDNF IGF-I | BDNF IGF-I |
M1 Microglia Markers
Subcellular Localization | Markers | |
Cytoplasmic | iNOS | COX-2 |
Cell Surface |
B7-1/CD80 B7-2/CD86 CD11b/Integrin aM CD36/SR-B3 CD40/TNFRSF5 |
CD68/SR-D1 Fcg RII/CD32 Fcg RIII/CD16 HLA-DR MHC Class II |
Secreted |
CCL2/JE/MCP-1 CCL4/MIP-1b CXCL1/GROa/KC/CINC-1 CXCL10/IP-10 IFN-g IL-1b/IL-1F2 |
IL-6 IL-12 IL-17/IL-17A IL-18/IL-1F4 Nitric Oxide TNF-a |
M2 Microglia Markers
Subcellular Localization | Markers | |
Nuclear | PPARg/NR1C3 | |
Cytoplasmic | Arginase 1/ARG1 Transglutaminase 2/TGM2 | Arginase 1/ARG1 Transglutaminase 2/TGM2 |
Cell Surface |
CD163 CLEC10A/CD301 DC-SIGN/CD209 HLA-DR MHC Class II |
MMR/CD206 Siglec-3/CD33 SR-AI TREM-2 |
Secreted |
BDNF FIZZ1/RELMa IGF-I IL-1ra/IL-1F3 IL-4 |
IL-10 IL-13 TGF-b YM1/Chitinase 2-like 3 |
Creative Biolabs provides a series of research tools needed to study the activation status of different microglia. Our product portfolio includes monoclonal antibodies, polyclonal antibodies, labeled antibodies, proteins, analytical kits, and small molecule activators and inhibitors.
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CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Alexa Fluor® 488
![](static/images/product/product-icon-neural-antibodies.png)
CD45 Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Mouse
- Applications:
- FCM
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3439
![](static/images/product/product-icon-neural-antibodies.png)
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Unconjugated
![](static/images/product/product-icon-neural-antibodies.png)
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-P
- Conjugation:
- Unconjugated
![](static/images/product/product-icon-neural-antibodies.png)
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Rat
- Applications:
- FCM
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3435
![](static/images/product/product-icon-neural-antibodies.png)
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3434
![](static/images/product/product-icon-neural-antibodies.png)
CD45 Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Unconjugated
![](static/images/product/product-icon-neural-antibodies.png)
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-P
- Conjugation:
- Unconjugated
![](static/images/product/product-icon-neural-antibodies.png)
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-Fr; IHC-P
- Conjugation:
- Unconjugated
![](static/images/product/product-icon-neural-antibodies.png)
CD45 Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Mouse
- Applications:
- IP; ICC; IF; FCM; IHC-Fr
- Conjugation:
- Unconjugated
![](static/images/product/product-icon-neural-antibodies.png)
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat
- Applications:
- FCM; ICC; IF; IHC-Fr
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3431
![](static/images/product/product-icon-neural-antibodies.png)
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IP; IHC-Fr; IHC-P; WB; FCM; ICC; IF
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3429
![](static/images/product/product-icon-neural-antibodies.png)
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM; IP; IHC-P; WB; ICC; IF
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3424
![](static/images/product/product-icon-neural-antibodies.png)
CD45 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- WB; IHC-P; ICC; IP
- Conjugation:
- Unconjugated
![](static/images/product/product-icon-neural-antibodies.png)
CD45 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Human
- Applications:
- IHC-P; WB; IP
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3420
![](static/images/product/product-icon-neural-antibodies.png)
CD45 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- WB; FCM; ICC; IF; IHC-P; IHC-Fr
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3415
![](static/images/product/product-icon-neural-antibodies.png)
Microglia
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC; WB
- NeuroMab™ Anti-PVRIG Antibody(NRP-0422-P792) (Cat#: NRP-0422-P792)
- NeuroMab™ Anti-PVRIG Antibody(NRP-0422-P1803) (Cat#: NRP-0422-P1803)
- NeuroMab™ Anti-Amyloid Beta 1-15 Antibody(NRP-0422-P867) (Cat#: NRP-0422-P867)
- NeuroMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P1684) (Cat#: NRP-0422-P1684)
- NeuroMab™ Anti-ApoC3 BBB Shuttle Antibody(NRZP-1022-ZP3505) (Cat#: NRZP-1022-ZP3505)
- NeuroMab™ Anti-pTau Antibody(NRP-0422-P1719) (Cat#: NRP-0422-P1719)
- NeuroMab™ Anti-F-Spondin/SPON1 Antibody, Clone N24875P (CBP11839) (Cat#: NRZP-0822-ZP4740)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P2275) (Cat#: NRP-0422-P2275)
- NeuroMab™ Anti-GARP Antibody(NRP-0422-P1639) (Cat#: NRP-0422-P1639)
- Rat Schwann Cells RSC96, Immortalized (Cat#: NCL-2108P21)
- Human Brain Microvascular Endothelial Cells (Cat#: NCL-2103-P133)
- Human Astrocytes, Immortalized (Cat#: NCL-2105-P182-AM)
- iNeu™ Microglia (Cat#: NCL-7P018)
- Human CMEC/D3 Cell Line, Blood-Brain Barrier Model (Cat#: NCL-2108-P020)
- Mouse Glioma Cell Line GL261 (Cat#: NCL-2108P28)
- Mouse Retinal Ganglion Cell Line RGC-5 (Cat#: NCL2110P154)
- Human Brain Vascular Adventitial Fibroblasts (Cat#: NCL-21P6-014)
- iNeu™ Retinal Pigment Epithelial Cells (RPE) (Cat#: NRZP-0323-ZP92)
- Human Brain Astroblastoma U-87 MG (Cat#: NCL2110P117)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Beta Amyloid (1-40), Aggregation Kit, TTF Assay (Cat#: NRZP-0323-ZP199)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- AAV-EF1a-mCherry-flex-dtA (Cat#: NRZP-0622-ZP616)
- Dextran, NHS Activated, 40 kDa (Cat#: NRZP-0722-ZP124)
- pAAV-syn-jGCaMP8m-WPRE (Cat#: NTA-2106-P062)
- AAV2/9-hEF1a-DIO-mCherry-P2A-TetTox-WPRE-pA (Cat#: NTA-2012-ZP268)
- Dextran-CYanine5.5 (Cat#: NTA-2011-ZP118)
- rAAV-E-SARE-Cre-ERT2-PEST-WPRE-hGH polyA (Cat#: NTA-2010-TT342)
- pAAV-EF1a-DIO-EGFP-WPRE (Cat#: NTA-2012AD-P285)
- rAAV-CAG-DIO-G-Flamp1 (Cat#: NRZP-0722-ZP719)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)