Product
Mouse Anti-GLP1R Monoclonal Antibody (CBP2143)
[CAT#: NAB-2011-ZP71]
- Host Species:
- Mouse
- Species Reactivity:
- human
- Applications:
- FC; ELISA
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
GLP1R binds specifically the glucagon-like peptide-1 (GLP1) and has much lower affinity for related peptides such as the gastric inhibitory polypeptide and glucagon. GLP1R is known to be expressed in pancreatic beta cells. Activated GLP1R stimulates the adenylyl cyclase pathway which results in increased insulin synthesis and release of insulin. Consequently, GLP1R has been suggested as a potential target for the treatment of diabetes. GLP1R is also expressed in the brain where it is involved in the control of appetite. Furthermore, mice which over express GLP1R display improved memory and learning.
Species Reactivity
human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1,κ
Clone Number
CBP2143
Applications
FC; ELISA
Application Notes
Working concentrations for specific applications should be determined by the investigator. The appropriate concentration may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined.
The following concentration ranges are recommended starting points for this product.
ICC/IF: 4 µg/ml
Flow cytometry: 1-5 µg/ml
ELISA: 0.1 µg/ml
Other Applications: user-optimized
The following concentration ranges are recommended starting points for this product.
ICC/IF: 4 µg/ml
Flow cytometry: 1-5 µg/ml
ELISA: 0.1 µg/ml
Other Applications: user-optimized
Product Properties
Concentration
0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
The lyophilized product remains stable up to 1 years at -20 °C from date of receipt. Upon reconstitution, it can be stored for 2-3 weeks at 2-8 °C or for up to 12 months at -20 °C or below. Avoid repeated freezing and thawing cycles.
Handling Advice
Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/ml.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
GLP1R
Official Name
GLP1R
Full Name
Glucagon Like Peptide 1 Receptor
Alternative Names
Glucagon Like Peptide 1 Receptor; Glucagon-Like Peptide 1 Receptor; GLP-1 Receptor; GLP-1-R; GLP-1R; Seven Transmembrane Helix Receptor; GLP1 Receptor; GLP-1;
Data
 hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]){kind=spacer}
Publications
Publications (0)
Neural Cell Lines
Neural Antibodies
For Research Use Only. Not For Clinical Use.
