Mouse Anti-GLP1R Monoclonal Antibody (CBP2143)

Product Overview

Description

GLP1R binds specifically the glucagon-like peptide-1 (GLP1) and has much lower affinity for related peptides such as the gastric inhibitory polypeptide and glucagon. GLP1R is known to be expressed in pancreatic beta cells. Activated GLP1R stimulates the adenylyl cyclase pathway which results in increased insulin synthesis and release of insulin. Consequently, GLP1R has been suggested as a potential target for the treatment of diabetes. GLP1R is also expressed in the brain where it is involved in the control of appetite. Furthermore, mice which over express GLP1R display improved memory and learning.

Species Reactivity

human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1,κ

Clone Number

CBP2143

Applications

FC; ELISA

Application Notes

Working concentrations for specific applications should be determined by the investigator. The appropriate concentration may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined.
The following concentration ranges are recommended starting points for this product.
ICC/IF: 4 µg/ml

Flow cytometry: 1-5 µg/ml

ELISA: 0.1 µg/ml

Other Applications: user-optimized

Product Properties

Concentration

0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

The lyophilized product remains stable up to 1 years at -20 °C from date of receipt. Upon reconstitution, it can be stored for 2-3 weeks at 2-8 °C or for up to 12 months at -20 °C or below. Avoid repeated freezing and thawing cycles.

Handling Advice

Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/ml.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

GLP1R

Official Name

GLP1R

Full Name

Glucagon Like Peptide 1 Receptor

Alternative Names

Glucagon Like Peptide 1 Receptor; Glucagon-Like Peptide 1 Receptor; GLP-1 Receptor; GLP-1-R; GLP-1R; Seven Transmembrane Helix Receptor; GLP1 Receptor; GLP-1;