Mouse Anti-PKCα Monoclonal Antibody (CBP2285)

[CAT#: NAB2010219LS]

Anti-PKCα Monoclonal Antibody

Host Species:: Mouse

Species Reactivity:: Human; Mouse; Rat

Applications:: WB; IHC-P

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Product Overview

Description

Protein Kinase C Alpha (PKCα) is a member of protein kinase C family, which is calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase. It has been reported to be involved in many cellular processes including cell proliferation, apoptosis, differentiation, migration and adhesion by directly phosphorylating targets such as BCL2, CSPG4, TNNT2/CTNT, or activating signaling pathways such as MAPK1/3 (ERK1/2) and RAP1GAP. PKCα is involved in neural development and transactivation of EGFR by gastrin, and it is also associated with diseases including chordoid glioma and myotonic dystrophy Type 1.

Immunogen

Synthetic peptide corresponding to human PKCα

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a, κ

Clone Number

CBP2285

Applications

WB; IHC-P

Application Notes

WB (0.05-0.5 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

PKCα

Official Name

PKCα

Full Name

Protein kinase C

Alternative Names

c Alpha; PKC-Alpha; EC 2.7.11.13; AAG6

References

1. Colgan LA, et al. 2018. Nat Neurosci. 21(8):1027-1037.
2. Gleize V, et al. 2018. Nat Commun. 9(1):2371.
3. Trubiani O, et al. 2016. Cell Signal. 28(11):1631-41.

Publications