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Creative Biolabs

Mouse Anti-Human FMRP Monoclonal Antibody (CBP4371)

[CAT#: NAB2101161LS]

Anti-FMRP Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB; ICC

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Product Overview

Description

The gene encoding Fragile X mental retardation protein 1 (FMRP or FMR1), also known as premature ovarian failure 1 (POF1), contains multiple CGG sequence repeats that are positively correlated with impaired cognitive and reproductive function. FMRP may be involved in mRNA transport and synaptic protein synthesis. The gene that encodes FMRP is located in the X chromosome, and an abnormally large number of CGG repeats (200 - 1000 times) causes Fragile X syndrome due to inadequate amounts of FMRP, leading to severe learning deficiency and mental retardation.

Immunogen

This monoclonal antibody was raised against a recombinant protein isolated from baculovirus.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP4371

Applications

WB; ICC

Application Notes

WB ( 2.0-10 µg/mL); ICC (5.0-10 μg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated
Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

1 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.
Target

Target

FMRP

Official Name

FMRP

Full Name

Helix Aspersa

Alternative Names

FMRF-like peptide

Gene ID

2332(Human); 14265(Mouse); 24948(Rat)

Uniprot ID

Q06787(Human); P35922(Mouse); Q80WE1(Rat)
Publications

Publications (0)

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