Mouse Anti-Human SEMA4A Monoclonal Antibody (CBP4362)

Product Overview

Description

Semaphorin 4A (SEMA4A) is a class IV semaphorin of soluble and transmembrane proteins originally identified as SemB. It is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain, and a Sema domain. SEMA4A is expressed on dendritic cells, activated B cells, and T cells. It is also found on different tissues, such as those in brain, lung, kindney, spleen, and testis. In the immune system, SEMA4A functions as an activator in the T-cell-mediated immune response and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Like other semaphorin family members it is also involved in guidance of axonal migration during neuronal development and in immune responses.

Immunogen

Mouse SEMA4A-Fc proteins

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, λ

Clone Number

CBP4362

Applications

Application Notes

FCM ( ≤0.125 µg per million cells in 100 µl volume)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

APC

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

SEMA4A

Official Name

SEMA4A

Full Name

Semaphorin 4A

Alternative Names

Semaphorin 4A; Sema Domain; Immunoglobulin Domain (Ig); Transmembrane Domain (TM) And Short Cytoplasmic Domain; (Semaphorin) 4A; Semaphorin-B; Sema B; SEMAB; SEMB; Semaphorin-4A; CORD10; RP35;