Mouse Anti-ITGAM Monoclonal Antibody (CBP1538)

Product Overview

Description

Mouse anti-Dog CD11b antibody is a monoclonal antibody that recognizes canine CD11b cell surface antigen (a member of the alpha integrin family). CD11b forms one of the possible alpha chains of the canine leukocyte adhesion complex (LeuCAM). They contain a common 95 kDa beta chain (CD18) that is non-covalently bound to 150 kDa (CD11c), 165 kDa (CD11b) or 180 kDa. (CD11a) alpha chain (Moore et al., 1990. The CD11/CD18 complex is also known as the CR3 receptor.
Canine CD11b is expressed by granulocytes, monocytes, NK cells and some macrophages. Mouse anti-Dog CD11b antibody has been used to evaluate the effect of anesthetic administration of CD11b expression on canine neutrophils (Maeda et al. 2010), which proves that CD11b expression is weakened after high concentration lidocaine hydrochloride administration, and neutrophils The adhesion to the endothelium is reduced.

Immunogen

Affinity purified beta-2 integrins from splenic lysate.

Species Reactivity

Dog; Goat; Cat; Mustelid; Porcine; Bovine; Mink; Beluga whale

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP1538

Applications

FC; IP; IHC-Fr

Relevant Diseases

Alzheimer's Disease

Research Areas

Growth and Development

Conjugation

Unconjugated

Product Properties

Form

Tissue Culture Supernatant-liquid

Formulation

Tissue Culture Supernatant-PBS
0.09% Sodium Azide

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred.

This product should be stored undiluted.

Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Target

CD11b

Official Name

ITGAM

Full Name

Integrin alpha M

Alternative Names

ITGAM; CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6; integrin subunit alpha M

Gene ID

3684 (Human); 16409 (Mouse); 25021 (Rat)

Uniprot ID

P11215 (Human); P05555 (Mouse)

References

1. Yuasa, K. et al. (2007) Injection of a recombinant AAV serotype 2 into canine skeletal muscles evokes strong immune responses against transgene products.
2. Kamstock, D. et al. (2006) Liposome-DNA complexes infused intravenously inhibit tumor angiogenesis and elicit antitumor activity in dogs with soft tissue sarcoma.
3. Sherger, M. et al. (2012) Identification of myeloid derived suppressor cells in the peripheral blood of tumor bearing dogs.
4. Gregorevic, P. et al. (2009) Evaluation of vascular delivery methodologies to enhance rAAV6-mediated gene transfer to canine striated musculature.
5. Figueiredo, M.M. et al. (2013) Expression of Toll-like Receptors 2 and 9 in cells of dog jejunum and colon naturally infected with Leishmania infantum.

Publications