NoGeneST™ Anti-CHD8 Aptamer, aCHD8 aptamer

Name: NoGeneST™ Anti-CHD8 Aptamer, aCHD8 aptamer
SKU: NRYF-0625-HZ112
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ112]

Aptamer designed to specifically recognize Chromodomain-Helicase-DNA-Binding Protein 8, a key chromatin remodeler strongly linked to Autism Spectrum Disorder.

Target:: CHD8

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Product Overview

Relevant Diseases

Autism Spectrum Disorder

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

CHD8

Full Name

Chromodomain-Helicase-DNA-Binding Protein 8

Gene ID

57438

Uniprot ID

Q86W56

Target Overview

Chromodomain-helicase-DNA-binding protein 8 (CHD8) is an ATP-dependent chromatin remodeling enzyme that plays a fundamental role in regulating gene expression. By using the energy from ATP hydrolysis, it alters the structure of chromatin, which is the complex of DNA and proteins within the nucleus. This remodeling activity controls the accessibility of DNA to the transcriptional machinery, thereby turning genes on or off. CHD8 is critically important during early brain development. Its significance is underscored by strong genetic evidence identifying disruptive, loss-of-function mutations in the CHD8 gene as one of the most common high-confidence risk factors for Autism Spectrum Disorder (ASD).

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