NoGeneST™ Anti-SMN1 Aptamer, aSMN1 aptamer

Name: NoGeneST™ Anti-SMN1 Aptamer, aSMN1 aptamer
SKU: NRYF-0625-HZ104
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ104]

Aptamer designed to specifically recognize Survival Motor Neuron 1 protein, the key protein deficient in Spinal Muscular Atrophy (SMA).

Target:: SMN1

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Product Overview

Relevant Diseases

Spinal Muscular Atrophy

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

SMN1

Full Name

Survival Motor Neuron Protein

Alternative Names

SMN; SMNT

Gene ID

6606

Uniprot ID

Q16637

Target Overview

Survival Motor Neuron Protein SMN1 is a protein that is essential for the survival of all cells, with a particularly critical role in motor neurons. It is a key component of a complex responsible for the assembly of small nuclear ribonucleoproteins (snRNPs), which are the fundamental building blocks of the spliceosome. The spliceosome carries out pre-mRNA splicing, a crucial step in gene expression. The loss of the SMN1 gene through homozygous deletion or mutation leads to a deficiency of functional SMN protein. This deficiency is the direct cause of Spinal Muscular Atrophy (SMA), a severe and progressive neuromuscular disease.

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