NoGeneST™ Anti-Nrf2 Aptamer, aNrf2 aptamer

Name: NoGeneST™ Anti-Nrf2 Aptamer, aNrf2 aptamer
SKU: NRYF-0625-HZ116
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ116]

Aptamer designed to specifically recognize Nrf2, the master regulator of the cellular antioxidant response.

Target:: Nrf2

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Product Overview

Relevant Diseases

Stroke

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

Nrf2

Full Name

Nuclear Factor Erythroid 2-Related Factor 2

Gene ID

4780

Uniprot ID

Q16236

Target Overview

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that serves as the master regulator of the cellular defense system against oxidative stress. Under normal conditions, Nrf2 is kept inactive in the cytoplasm by its inhibitor, KEAP1. In response to oxidative stress, Nrf2 is stabilized, moves into the nucleus, and activates the transcription of hundreds of antioxidant, detoxification, and cytoprotective genes. While this pathway is crucial for protecting against aging and chronic disease, it is often hijacked by cancer cells to promote their survival and resistance to chemotherapy.

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