NoGeneST™ Anti-C9orf72 Aptamer, aC9orf72 aptamer

Name: NoGeneST™ Anti-C9orf72 Aptamer, aC9orf72 aptamer
SKU: NRYF-0625-HZ103
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ103]

Aptamer designed to specifically recognize Protein C9orf72, a protein linked to the most common genetic cause of ALS and FTD.

Target:: C9orf72

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Product Overview

Relevant Diseases

Amyotrophic Lateral Sclerosis

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

C9orf72

Full Name

Protein C9orf72

Gene ID

203228

Uniprot ID

Q96LT7

Target Overview

The C9orf72 gene is most notable for a specific pathogenic mutation: a GGGGCC hexanucleotide repeat expansion located in a non-coding region of the gene. This expansion is the most common genetic cause of both Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). The mutation is believed to cause disease through multiple mechanisms, including a partial loss of the normal C9orf72 protein's function, the formation of toxic RNA aggregates (foci) that sequester other proteins, and the production of toxic dipeptide repeat proteins. The normal function of the C9orf72 protein is thought to be involved in regulating cellular trafficking and autophagy.

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