NoGeneST™ Anti-IL-23 Aptamer, aIL-23 aptamer

Name: NoGeneST™ Anti-IL-23 Aptamer, aIL-23 aptamer
SKU: NRYF-0625-HZ108
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ108]

Aptamer designed to specifically recognize Interleukin-23, a heterodimeric cytokine central to the pathogenesis of Th17-mediated autoimmune diseases.

Target:: IL-23

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Product Overview

Relevant Diseases

Multiple Sclerosis

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

IL-23

Full Name

Interleukin-23

Target Overview

nterleukin-23 (IL-23) is a heterodimeric cytokine composed of two distinct subunits: the p19 subunit (encoded by the IL23A gene) and the p40 subunit (encoded by the IL12B gene), the latter of which is shared with the cytokine IL-12. IL-23 is a key regulator of chronic inflammation and autoimmunity. Its primary function is to drive the expansion and maintenance of a specific subset of T helper cells known as Th17 cells. These cells produce highly pro-inflammatory cytokines (like IL-17), making the IL-23/IL-17 axis a central pathway in the pathology of many autoimmune diseases, including psoriasis, Crohn's disease, and psoriatic arthritis.

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