NoGeneST™ Anti-GRN Aptamer, aGRN aptamer

Name: NoGeneST™ Anti-GRN Aptamer, aGRN aptamer
SKU: NRYF-0625-HZ122
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ122]

Aptamer designed to specifically recognize Progranulin, a growth factor and lysosomal protein linked to frontotemporal dementia.

Target:: GRN

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Product Overview

Relevant Diseases

Frontotemporal Dementia

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

GRN

Full Name

Progranulin

Gene ID

2896

Uniprot ID

P28799

Target Overview

Progranulin (GRN) is a secreted growth factor involved in a variety of cellular processes, including cell proliferation, wound healing, and inflammation. In the central nervous system, it also plays a critical role in lysosomal function and neuronal survival. The importance of Progranulin in brain health is underscored by the fact that heterozygous loss-of-function mutations in the GRN gene are a major cause of inherited Frontotemporal Dementia (FTD), a progressive neurodegenerative disorder. This deficiency, known as progranulin haploinsufficiency, leads to lysosomal dysfunction and is often associated with the pathological aggregation of TDP-43 protein, marking GRN as a key therapeutic target for FTD.

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