NoGeneST™ Anti-KCNQ2 Aptamer, aKCNQ2 aptamer

Name: NoGeneST™ Anti-KCNQ2 Aptamer, aKCNQ2 aptamer
SKU: NRYF-0625-HZ99
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ99]

Aptamer designed to specifically recognize the Kv7.2 potassium channel subunit, a key regulator of neuronal excitability implicated in epilepsy.

Target:: KCNQ2

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Product Overview

Relevant Diseases

Epilepsy

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

KCNQ2

Full Name

Potassium Voltage-Gated Channel Subfamily KQT Member 2

Alternative Names

Kv7.2; EBN1; BFNC

Gene ID

3785

Uniprot ID

O43526

Target Overview

KCNQ2 is a voltage-gated potassium channel subunit that is crucial for regulating neuronal excitability. It co-assembles with the related KCNQ3 subunit to form the channel that generates the "M-current," a slow, non-inactivating potassium current. This M-current acts as a powerful brake on repetitive neuron firing, thereby stabilizing the membrane potential and preventing hyperexcitability. Loss-of-function mutations in the KCNQ2 gene are a primary cause of neonatal epileptic encephalopathies, as the resulting impairment of the M-current leads to severe seizures.

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