NoGeneST™ Anti-FUS Aptamer, aFUS aptamer

Name: NoGeneST™ Anti-FUS Aptamer, aFUS aptamer
SKU: NRYF-0625-HZ102
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ102]

Aptamer designed to specifically recognize RNA-Binding Protein FUS, a key protein implicated in Amyotrophic Lateral Sclerosis (ALS).

Target:: FUS

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Product Overview

Relevant Diseases

Amyotrophic Lateral Sclerosis

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

FUS

Full Name

RNA-Binding Protein FUS

Alternative Names

TLS

Gene ID

2521

Uniprot ID

P35637

Target Overview

FUS (Fused in Sarcoma) is a DNA/RNA-binding protein that is predominantly located in the nucleus and plays a crucial role in various aspects of RNA metabolism, including transcription, pre-mRNA splicing, and RNA transport. FUS is strongly linked to neurodegenerative disease; mutations in the FUS gene are a known cause of familial Amyotrophic Lateral Sclerosis (ALS). In these diseases, a key pathological feature is the mislocalization of the FUS protein from the nucleus to the cytoplasm, where it forms insoluble aggregates. These FUS-positive inclusions are hallmarks of certain forms of ALS and Frontotemporal Lobar Degeneration (FTLD-FUS).

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