NoGeneST™ Anti-SCN1A Aptamer, aSCN1A aptamer

Name: NoGeneST™ Anti-SCN1A Aptamer, aSCN1A aptamer
SKU: NRYF-0625-HZ96
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ96]

Aptamer designed to specifically recognize Sodium Channel Protein Type 1 Subunit Alpha (Nav1.1), a critical ion channel implicated in epilepsy.

Target:: SCN1A

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Product Overview

Relevant Diseases

Epilepsy

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

SCN1A

Full Name

Sodium Channel Protein Type 1 Subunit Alpha

Alternative Names

Nav1.1; NAC1

Gene ID

6323

Uniprot ID

P35498

Target Overview

The SCN1A gene codes for the alpha subunit of the Nav1.1 voltage-gated sodium channel. This channel is a key component in the brain for initiating and propagating action potentials, particularly in inhibitory interneurons. By controlling the flow of sodium ions, SCN1A plays a crucial role in regulating neuronal excitability and maintaining the proper balance between excitation and inhibition in the central nervous system. Loss-of-function mutations in the SCN1A gene are the primary cause of Dravet syndrome, a severe form of pediatric epilepsy, and are associated with a spectrum of other seizure disorders.

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