NoGeneST™ Anti-TDP-43 Aptamer, aTDP-43 aptamer

Name: NoGeneST™ Anti-TDP-43 Aptamer, aTDP-43 aptamer
SKU: NRYF-0625-HZ101
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ101]

Aptamer designed to specifically recognize TAR DNA-Binding Protein 43, a key protein in the pathology of ALS and FTLD.

Target:: TDP-43

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Product Overview

Relevant Diseases

Amyotrophic Lateral Sclerosis

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

TDP-43

Full Name

TAR DNA-Binding Protein 43

Alternative Names

TDP43

Gene ID

23435

Uniprot ID

Q13148

Target Overview

TAR DNA-binding protein 43 (TDP-43) is a highly conserved protein that primarily resides in the nucleus and is critically involved in RNA processing, including transcription, alternative splicing, and mRNA stability. TDP-43 is most notable for its central role in neurodegenerative diseases. In nearly all cases of Amyotrophic Lateral Sclerosis (ALS) and over half of the cases of Frontotemporal Lobar Degeneration (FTLD), TDP-43 becomes pathologically altered. It mislocalizes from the nucleus to the cytoplasm, becomes hyperphosphorylated and ubiquitinated, and aggregates into insoluble inclusions within neurons. This "proteinopathy" is a defining pathological hallmark of these diseases.

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