Amyotrophic Lateral Sclerosis Related Research Tools
Amyotrophic lateral sclerosis (ALS) is a disease that causes the death of the neurons controlling voluntary muscles. It is also known as Lou Gehrig's disease, Charcot's disease or motor neurone disease (MND). Over 17,000 people are estimated to be living with ALS in the United States, more commonly in whites, males, and people over the age of 60. The ALS symptoms include stiff muscles, muscle twitching, and gradually worsening weakness due to muscles decreasing in size.
ALS can be classified as familial or sporadic ALS. It has been shown that more than 20 genes are associated with familial ALS, of which four account for the majority of familial cases: C9orf72 (40%), SOD1 (20%), FUS (1-5%), and TARDBP (1-5%). Other genes include CHCHD10, SQSTM1, and TBK1. These genes can be grouped into three general categories: protein degradation, the cytoskeleton, and RNA processing.
Pathophysiology of ALS
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Creative Biolabs offers a range of research reagents needed for ALS investigation. Our products include monoclonal antibodies, polyclonal antibodies, labeled antibodies, recombinant proteins, analytical kits, cell lines, small molecule activators and inhibitors.
Related Genes of Amyotrophic Lateral Sclerosis (ALS)
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Related Pathways of Amyotrophic Lateral Sclerosis (ALS)
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For Research Use Only. Not For Clinical Use.
Target
Related Products
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Mouse Anti-Human TARDBP (CBP5569) [CAT#: NAB210504SL]
Anti-TARDBP Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IF; IHC; IP; ELISA; WB
- Conjugation:
- Unconjugated
NeuroMab™ Mouse Anti-TDP43 Monoclonal Antibody (CBP2545) [CAT#: NAB2007FY927]
Mouse Monoclonal [2E2-D3] to TDP43
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IF; IHC-P; WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1857
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