Oligodendrocyte Marker Related Research Reagents
![Oligodendrocyte Markers](static/img/1-2-4-1-2-Oligodendrocyte-Markers-1.png)
Oligodendrocytes (ODs) are glial cells in the central nervous system (CNS) that form the myelin sheath of axons to support rapid nerve conduction. OD also contributes to neuroplasticity and provides nutritional support for neurons. Each OD can interact with multiple axons and has the ability to quickly update its myelin sheath. Each myelin sheath of oligodendrocytes has up to 50 independent axons. As a result, OD has a high metabolic rate and is very susceptible to oxidative stress. OD is highly sensitive to pro-inflammatory molecules produced during inflammation and responds by producing low-quality myelin. In addition, OD can also affect neuronal survival, axon transport, axon caliber, and ion channel aggregation along the axon. OD damage and dysfunction are responsible for the development of many diseases and conditions, including multiple sclerosis, schizophrenia, and bipolar disorder.
Each stage of oligodendrocyte differentiation and maturation can be monitored by the specific morphology markers, including the most common maturation stage markers CNPase, Olig2 and oligodendrocyte marker O4. Creative Biolabs provides a series of research tools needed to study the development, maturation and function of oligodendrocytes. Our product portfolio includes monoclonal antibodies, polyclonal antibodies, labeled antibodies, proteins, analytical kits, and small molecule activators and inhibitors.
Summary of Oligodendrocyte Markers Provided by Creative Biolabs
Oligodendrocyte Precursor Cell Markers
Subcellular Localization | Markers | |
Nuclear |
NKX2.2 Olig2 |
SOX10 |
Cytoplasmic | Olig2 | |
Cell Surface |
A2B5 NG2/MCSP |
Oligodendrocyte Marker O4 PDGF Rα |
Immature Oligodendrocyte Markers
Subcellular Localization | Markers | |
Cytoplasmic | CNPase | |
Cell Surface | Oligodendrocyte Marker O1 | Oligodendrocyte Marker O4 |
Non-Myelinating Oligodendrocyte Markers
Subcellular Localization | Markers | |
Cytoplasmic |
CNPase Nogo-A |
APC |
Cell Surface |
Oligodendrocyte Marker O1 Myelin PLP |
Oligodendrocyte Marker O4 |
Myelinating Oligodendrocyte Markers
Subcellular Localization | Markers | |
Cytoplasmic |
CNPase TPPP/p25 MBP |
APC OMgp Nogo-A |
Cell Surface |
Caspr2 MAG/Siglec-4a |
MOG Myelin PLP |
Target
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Caspr2/CNTNAP2 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3405
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Caspr2/CNTNAP2 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3401
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- NeuroMab™ Anti-Tau Antibody(NRP-0422-P2275) (Cat#: NRP-0422-P2275)
- NeuroMab™ Anti-GD2 Antibody(NRZP-1222-ZP767) (Cat#: NRZP-1222-ZP767)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P1684) (Cat#: NRP-0422-P1684)
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- NeuroMab™ Mouse Anti-LRP1 Monoclonal Antibody (CBP3363) (Cat#: NAB-0720-Z6479)
- NeuroMab™ Anti-TNFα BBB Shuttle Antibody(NRZP-1022-ZP4105) (Cat#: NRZP-1022-ZP4105)
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- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
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