Aptamer Products

While monoclonal antibodies have long been the cornerstone of molecular recognition, their inherent production variability, immunogenicity, and limited chemical tractability present significant challenges in modern diagnostics, therapeutics, and research. Aptamers have emerged as a superior class of synthetic affinity reagents engineered to overcome these constraints. These structured, single-stranded DNA or RNA oligonucleotides, identified through a proprietary in vitro selection process (SELEX), are designed to fold into unique conformations that bind their targets with affinities and specificities often rivaling or exceeding those of antibodies. Their purely chemical synthesis ensures unparalleled batch-to-batch consistency, exceptional stability, and a unique amenability to precise site-specific modification, establishing them as the definitive affinity tool for next-generation applications.

Fig.1 Aptamer 3D Structure and Target Binding.¹

Why Choose Creative Biolabs?

Our comprehensive expertise and proprietary platforms make us the ideal partner for your aptamer-based projects. We offer an integrated, end-to-end solution that covers every stage of aptamer development, ensuring you receive a reagent perfectly tailored to your needs.

1. Unrivaled Custom Discovery and Selection: We don't believe in a one-size-fits-all approach. Our process begins with our AptaLib™ service, generating diverse, high-complexity aptamer libraries that form the foundation for successful discovery. From there, our specialized screening platforms are deployed based on your target type:

• ProApta™: For high-affinity aptamer discovery against protein targets.
• CellApta™: Utilizing advanced technology for the identification of aptamers that recognize specific cell-surface markers.
• SmolApta™: Designed to overcome the challenges of finding binders for small molecules.
• MetApta™: Focused on the precise detection of specific metal ions.

2. Advanced Engineering and Tailored Modifications: A powerful aptamer is one that integrates seamlessly into your application.

Our BiApta™ bispecific aptamer engineering service allows for the creation of novel constructs with dual-target functionality. Furthermore, through our AptaMod™ platform, we provide a vast array of tailored aptamer modifications. Whether you require conjugation to fluorophores for imaging, biotin for immobilization, or nanoparticles for drug delivery, we can functionalize your aptamer for optimal performance.

3. Guaranteed Quality and Scalable Synthesis: As synthetic molecules, aptamers bypass the biological variability of antibodies.

Our AptaSyn™ custom synthesis platform ensures the highest purity and unparalleled batch-to-batch consistency. Every aptamer we produce undergoes rigorous quality control and validation, guaranteeing reliable performance in your hands, from small-scale research to large-scale manufacturing.

Applications of Aptamers

The unique advantages of aptamers have unlocked new possibilities across a wide spectrum of scientific disciplines. At Creative Biolabs, we develop aptamers that are empowering innovation and driving progress in:

• Diagnostics: Aptamers' robustness and specificity make them ideal for developing next-generation biosensors, lateral flow assays, and ELISA-like kits. Their stability allows for reliable performance even in point-of-care and field settings where environmental conditions can be harsh.
• Therapeutics: With their low immunogenicity and small size, aptamers are excellent candidates for targeted therapies. They can be engineered to deliver drug payloads directly to diseased cells, act as antagonists to block protein function, or serve as in vivo imaging agents.
• Basic and Applied Research: In the lab, aptamers are transforming fundamental techniques. They serve as superior ligands for affinity chromatography, reliable probes in Western blotting and flow cytometry (FACS), and essential components in complex molecular assemblies.
• Food Safety & Environmental Monitoring: The ability to generate aptamers against toxins, pesticides, and pathogens enables the rapid, specific, and cost-effective detection of contaminants, ensuring global safety and compliance.

Our Aptamer Screening Workflow

To learn more about our aptamer products, please contact us today.

Reference

1. Arshavsky-Graham, Sofia et al. "Aptasensors versus immunosensors-Which will prevail?." Engineering in life sciences vol. 22,3-4 319-333. 13 Jan. 2022, doi:10.1002/elsc.202100148. Distributed under Open Access License CC BY 4.0 without modification.

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NoGeneST™ Anti-GRN Aptamer, aGRN aptamer [CAT#: NRYF-0625-HZ122]

Aptamer designed to specifically recognize Progranulin, a growth factor and lysosomal protein linked to frontotemporal dementia.

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