Neonatal Ventral Hippocampal Lesion (NVHL) Model Development Service

Are you currently facing long drug development cycles, preclinical models that fail to accurately predict clinical outcomes, or challenges in identifying new therapeutic targets for neurodevelopmental disorders? Our neonatal ventral hippocampal lesion (NVHL) model development services help you accelerate drug discovery and de-risk your preclinical pipeline through a powerful and translatable animal model that accurately mimics the human disease trajectory.

The NVHL model is a preclinically validated animal model that mimics key neurodevelopmental risk factors for neuropsychiatric disorders. The model is based on the "two-hit" hypothesis, positing that a subclinical early-life insult to the brain can lead to the delayed emergence of behavioral and cognitive deficits in adulthood. This approach provides a powerful platform for understanding disease progression and evaluating the therapeutic potential of new compounds.

Workflow Advantages Available Models Offerings Related Services FAQs

How NVHL Model Development Services Can Assist Your Project

At Creative Biolabs, our NVHL model development services are designed to provide a comprehensive solution for your research needs. We offer a platform to test the efficacy of novel drug candidates and to elucidate the underlying neurobiological mechanisms of complex neuropsychiatric disorders. Our key problem-solving capabilities include establishing a reliable, reproducible NVHL model and providing a full suite of analytical services to evaluate therapeutic effects.

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Fig.1 Workflow of our Neonatal Ventral Hippocampal Lesion (NVHL) Model Development Services. (Creative Biolabs Original)

Workflow: A Clear Path to Results

Required Starting Materials	Specific Compound Information: Chemical structure and desired dosage range for your therapeutic agent. Project Scope and Research Questions: A clear outline of your study's objectives and the specific behaviors or biomarkers you aim to target. Reference Materials: Any relevant publications or preliminary data you have collected.
Final Deliverables	Comprehensive Study Report: A detailed document covering all aspects of the study, from methodology and raw data to statistical analysis and conclusions. Behavioral Data Sets: Clean, organized data files from all behavioral assays, ready for your own analysis and integration into your research. Molecular and Histological Analysis: Results from all neurochemical and immunohistochemical analyses, including protein quantification and neuronal morphology assessments.
Estimated Timeframe	The typical timeframe for this service ranges from 12 to 16 weeks, depending on the complexity of the study design and the scope of the behavioral and analytical endpoints.

Why Choose Us?

Our deep scientific expertise and unwavering commitment to quality set us apart. We have a proven track record of developing reliable and reproducible preclinical models that empower our clients to make significant advancements in their research.

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Customer Reviews

Using CBL's NVHL model development services in our research has significantly improved the translatability of our preclinical findings to the clinic. - 2024, J*ne R***s
The NVHL model provided by CBL has been instrumental in validating the mechanism of action of our new drug. The detailed neurochemical analysis provided invaluable insight into its effect on the NRG-1 pathway. - 2025, M*rk P***l

Neonatal Ventral Hippocampal Lesion (NVHL) Model

The NVHL model is a powerful tool because it embodies the "two-hit" hypothesis of neurodevelopmental disorders. By inducing a targeted lesion in the ventral hippocampus of rat pups on postnatal day 7 (PD 7) with a neurotoxin like ibotenic acid, the model mimics a critical early-life insult. This lesion, while not immediately apparent in terms of behavioral deficits, sets the stage for the emergence of robust, schizophrenia-like phenotypes during post-pubertal development. The model's predictive validity is derived from its ability to consistently reproduce a spectrum of behavioral, cognitive, and neurochemical deficits that are directly relevant to human symptoms. Our research and that of others have shown that this model leads to long-lasting dysregulation of key neural circuits, particularly those involving the prefrontal cortex (PFC) and the dopaminergic system. This is a crucial distinction and a powerful selling point for the model.

Fig.2 Experimental time course for protocol. (OA Literature) Fig.1 Experimental time course for NVHL model.¹

What We Can Offer

At Creative Biolabs, we provide a one-stop solution for your NVHL model needs, offering a seamless and integrated service from initial consultation to final data delivery. Our comprehensive platform is designed to streamline your preclinical research and maximize your success.

End-to-End Service: We handle every step of the process, from model development and maintenance to complex behavioral and neurobiological analyses. This allows your team to focus on core research and discovery.
Customized Protocols: Your project is unique. We provide fully customized service protocols to meet your specific research objectives and deliver the precise data you need to move your program forward.
Precision and Reproducibility: Our strict, well-established quality assurance system and aseptic verification procedures ensure the highest levels of consistency and reliability in every model we develop. This commitment to quality minimizes variability and maximizes the integrity of your data.
Advanced Analytical Capabilities: We employ a full suite of state-of-the-art analytical techniques to quantify and evaluate the quality of our results, including advanced molecular, histological, and electrophysiological assessments.
Optimized Conditions: We continuously optimize our culture conditions and procedures to maximize the relevance and predictive power of the model, ensuring the highest possible yield of actionable data for your team.

Related Services

To further assist your research, consider our other complementary services:

Target Identification & Validation
Compound Screening & Profiling
Pharmacokinetic/Pharmacodynamic (PK/PD) Studies
Neuroinflammation Research Models

FAQs

Q Is the NVHL model a true representation of schizophrenia?

A While no animal model can perfectly replicate the complexity of human disease, the NVHL model is widely considered one of the most translationally relevant platforms for studying schizophrenia-like behaviors. It accurately reproduces key features such as sensorimotor gating deficits and PFC dysfunction, making it an excellent tool for preclinical drug discovery.

Q Can your services be customized for our specific research needs?

A Absolutely. We understand that every project is unique. Our team of experts works closely with you to design a customized study protocol, including specific behavioral assays, drug administration schedules, and molecular endpoints that are most relevant to your research goals.

For more information and to discuss your project in detail, please do not hesitate to reach out to our team.

Contact Our Team for More Information and to Discuss Your Project.

Reference

Watanabe, Kenya et al. "Alterations in prefrontal cortical neuregulin-1 levels in post-pubertal rats with neonatal ventral hippocampal lesions." Frontiers in behavioral neuroscience vol. 16 1008623. 22 Dec. 2022, doi:10.3389/fnbeh.2022.1008623. Distributed under Open Access license CC BY 4.0, without modification.

For Research Use Only. Not For Clinical Use.

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