Attention-Deficit/Hyperactivity Disorder (ADHD) Mouse Model Development Service

Attention-Deficit/Hyperactivity Disorder (ADHD) Mouse Models Development Services, Accelerate Your Neurodevelopmental Drug Discovery! Are you currently facing the long development cycles and poor translational success common in neurodevelopmental research? Our ADHD Mouse Models services help you accelerate drug discovery and validate novel therapeutic targets through advanced CRISPR engineering and high-fidelity behavioral phenotyping. We provide models guaranteed for precision and robust clinical relevance.

ADHD is a complex neurodevelopmental disorder driven by polygenic factors and functional dysregulation within fronto-striatal brain circuits. Animal models are essential for dissecting the underlying molecular mechanisms, particularly involving the dopamine, norepinephrine, and serotonin systems. Creative Biolabs leverages advanced genetic tools, like CRISPR, to create high-fidelity models that achieve robust Construct and Predictive Validity, accelerating the transition from genetic hypothesis to therapeutic strategy. Our models allow researchers to test the efficacy of novel compounds against specific endophenotypes, providing clarity in a heterogeneous field.

Workflow Advantages Available Models Offerings Related Services FAQs

How Our ADHD Mouse Models Can Assist Your Project

Our services provide essential, genetically precise in vivo tools to dissect the intricate neurobiology of ADHD, test novel compounds against specific endophenotypes, and confirm the translational viability of your therapeutic candidates. We move you beyond general hyperactivity screens to targeted investigations of cognitive deficits and impulsivity, offering the most clinically relevant research platform available.

Workflow of our Attention-Deficit/Hyperactivity Disorder (ADHD) Mouse Models Development Services. (Creative Biolabs Original)

Workflow: From Concept to Validated Colony

Required Starting Materials	Gene Accession Number(s): The precise sequence and locus for the target gene (e.g., DAT1, STS). Proposed Mutation Details: Specific human SNP, insertion/deletion coordinates, or desired loxP sites for conditional expression. Target Brain Region/Cell Type: For cKO models, specification of the desired region-specific Cre-driver line (e.g., prefrontal cortex or striatum).
Final Deliverables	Genetically Validated Mouse Line: The stable, germline-transmitting colony ready for experimentation. Comprehensive Genotyping Report: Detailed molecular confirmation of the genetic modification. Full Behavioral Phenotyping Report: Data demonstrating Face and Predictive Validity across key ADHD endophenotypes.
Estimated Timeframe	The typical timeframe for a full Custom Genetic Model Generation and Validation ranges from 8 to 12 months, depending primarily on the complexity of the genetic modification (KI/cKO takes longer than conventional KO) and the necessary breeding time to establish experimental cohorts.

Why Choose Us?

Our 20 years of experience positions CBL as the gold standard in generating high-fidelity neurodevelopmental models. We specialize in complexity, providing solutions that address the limitations of conventional models.

Key Advantages and Unique Features

Guaranteed Model Delivery: We eliminate technical risk from your budget. We guarantee the successful development of your requested genetic line, or we continue the work until success is achieved.
Precision Genetic Engineering: We utilize advanced CRISPR/Cas9 for precise modifications like Conditional Knockouts (cKOs) and Humanized Knock-ins (KIs), ensuring your model is biologically relevant and temporally/spatially controlled.
Neurobiology Expertise: Our deep knowledge of the monoaminergic and non-monoaminergic systems allows us to design models that dissect the complex role of factors like Serotonergic Tone and Neurosteroid Modulators (GABA_A and NMDA receptor function) in ADHD pathophysiology.
Translational Assay Suite: Our internal validation includes the most sensitive cognitive and impulsive behavioral assays (5-CSRTT) to provide reliable Predictive Validity for drug screening.

Types of ADHD Mouse Models

The complexity of ADHD requires a diversity of models, moving beyond traditional spontaneous mutants to high-precision genetic engineering. Our expertise ensures we develop the most appropriate tool for your specific hypothesis, whether you are targeting core monoamines or subtle synaptic machinery.

Models	Description
Dopamine Transporter (DAT1) Models	The gold standard, central to DA reuptake and psychostimulant action. We focus on Conditional Knockouts (cKOs) using Cre-LoxP technology to allow for temporal and tissue-specific gene deletion (e.g., deleting DAT1 specifically in the prefrontal cortex or striatum), which avoids the severe developmental confounds of conventional KOs.
Synaptic Plasticity Models (Lphn3, SNAP-25)	These models target genes critical for neurotransmitter release and synaptic organization. Lphn3 Knock-ins model genetic susceptibility identified in GWAS, while SNAP-25 models address core issues of neurotransmitter vesicle fusion, often exhibiting hyperactivity and impaired inhibition.
Familial & Humanized Models (CDH2)	Utilizing CRISPR-mediated Humanized Knock-in (KI) Models to integrate specific human SNPs or familial mutations (e.g., the CDH2 mutation), these models offer the highest translational relevance for pharmacogenetic studies.
Novel Modulatory Pathway Models (STS)	We engineer models for emerging targets like Steroid Sulfatase (STS). These non-monoaminergic pathways regulate neurosteroids (DHEA/DHEA-S) that modulate key receptor systems (GABA_A} and NMDA), providing a critical platform to explore alternative drug targets for attention and impulsivity.

What We Can Offer

As an expert biology specialist, CBL provides a robust, high-standard platform for neurodevelopmental research, assuring that your ADHD mouse models are scientifically sound, compliant, and ready to yield critical translational data.

One-Stop Modeling & Validation: A comprehensive, end-to-end service from initial gene target design through to the delivery of a pharmacologically validated colony.
Unmatched Customization & Precision: Efficient CRISPR/Cas9 systems used to execute highly tailored projects—whether a single SNP Humanized Knock-in or a complex Conditional Knockout targeting specific neural circuits.
Scalable and Sustainable Cohorts: Established colony management protocols and state-of-the-art housing to provide large-scale experimental cohorts of different genetic backgrounds, ensuring sufficient statistical power for your studies.
Validated Quality System: A well-established quality system applying Quality-by-Design principles to ensure the genetic integrity and phenotypic stability of strains throughout the entire generation and breeding process.
Optimized Translational Fidelity: We run the phenotyping process in custom-designed behavioral paradigms to maximize the relevance of your data, focusing on high-value endophenotypes like sustained attention (5-CSRTT) and response inhibition (Go/No-Go).
Guaranteed Model Delivery: Our ironclad guarantee provides confidence that the genetic line you design is the functional model you will receive, mitigating major project risks.

Related Services

To ensure the success of your entire preclinical pipeline, CBL offers complementary services that integrate seamlessly with our ADHD Mouse Models.

Target Identification & Validation
Compound Screening & Profiling
Pharmacokinetic/Pharmacodynamic (PK/PD) Studies
Neuroinflammation Research Models

FAQs

Q How do your models address the challenge of ADHD's polygenic nature?

A ADHD is highly complex, involving multiple genes of small effect. We address this by offering Integrated Multi-Gene Models (double or triple KOs/KIs) and specialized Humanized Knock-in models that integrate specific human SNPs, allowing you to test gene-gene and gene-environment interactions directly, providing greater depth than single-gene models.

Q Can your ADHD models be utilized to screen for non-pharmacological interventions like neurotechnology?

A Absolutely. Our models, particularly those validated with the 5-Choice Serial Reaction Time Task (5-CSRTT) for attention and impulsivity, provide robust, objective behavioral endpoints. These endpoints are ideal for measuring the efficacy of non-pharmacological therapies such as Transcranial Magnetic/Direct Current Stimulation (tMS/tDCS) and other cognitive training paradigms.

For more information and to discuss how our services can meet your specific project requirements, please contact our team of experts.

Contact Our Team for More Information and to Discuss Your Project.

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