Mouse Anti-NSD2 Monoclonal Antibody (AB159)

Neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease and Huntington's disease The result of the gradual loss of neuron structure and function, Causes neuron death. This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4; 14)(p16.3; q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq, Jul 2008]

Binds to an located within the peptide sequence ALPFIPADKL

Human

Monoclonal

Mouse

IgG2b

AB159

IHC; WB; IF

IHC: 1:500-1:1000
WB: 1 µg/ml
IF: 2-10 µg/ml

Alzheimer's Disease; Huntington's Disease; Parkinson's Disease; Amyotrophic Lateral Sclerosis

Liquid

PBS, pH 7.2, 40% glycerol

0.02% Sodium azide

1 mg/ml

Protein A purified

Gel Pack

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

The antibody solution should be gently mixed before use.

For research use only

NSD2

NSD2

Nuclear Receptor Binding SET Domain Protein 2

Nuclear Receptor Binding SET Domain Protein 2; Nuclear SET Domain-Containing Protein 2; Wolf-Hirschhorn Syndrome Candidate 1; EC 2.1.1.43; WHSC1; MMSET; TRX5; Multiple Myeloma SET Domain Containing Protein Type III; Probable Histone-Lysine N-Methyltransferase NSD2; Multiple Myeloma SET Domain Containing Protein; Multiple Myeloma SET Domain-Containing Protein

7468(Human); 107823(Mouse)

O96028(Human); Q8BVE8(Mouse)