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Creative Biolabs
Product

Mouse Anti-NSD2 Monoclonal Antibody (CBP6765)

[CAT#: NAB2007FY1714]

Amyotrophic Lateral Sclerosis,
Parkinson's, Alzheimer's and Huntington's diseases

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC; WB; IF

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Product Overview

Description

Neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease and Huntington's disease The result of the gradual loss of neuron structure and function, Causes neuron death. This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4; 14)(p16.3; q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq, Jul 2008]

Epitope

Binds to an located within the peptide sequence ALPFIPADKL

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP6765

Applications

IHC; WB; IF

Application Notes

IHC: 1:500-1:1000
WB: 1 µg/ml
IF: 2-10 µg/ml

Relevant Diseases

Alzheimer's Disease; Huntington's Disease; Parkinson's Disease; Amyotrophic Lateral Sclerosis
Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only
Target

Target

NSD2

Official Name

NSD2

Full Name

Nuclear Receptor Binding SET Domain Protein 2

Alternative Names

Nuclear Receptor Binding SET Domain Protein 2; Nuclear SET Domain-Containing Protein 2; Wolf-Hirschhorn Syndrome Candidate 1; EC 2.1.1.43; WHSC1; MMSET; TRX5; Multiple Myeloma SET Domain Containing Protein Type III; Probable Histone-Lysine N-Methyltransferase NSD2; Multiple Myeloma SET Domain Containing Protein; Multiple Myeloma SET Domain-Containing Protein

Gene ID

7468(Human); 107823(Mouse)

Uniprot ID

O96028(Human); Q8BVE8(Mouse)
Publications

Publications (0)

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For Research Use Only. Not For Clinical Use.
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