Creative Biolabs

Mouse Anti-NSD2 Monoclonal Antibody (AB159)

[CAT#: NAB2007FY1714]

Amyotrophic Lateral Sclerosis,
Parkinson's, Alzheimer's and Huntington's diseases

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC; WB; IF

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Description
Neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease and Huntington's disease The result of the gradual loss of neuron structure and function, Causes neuron death. This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4; 14)(p16.3; q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq, Jul 2008]
Epitope
Binds to an located within the peptide sequence ALPFIPADKL
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2b
Clone Number
AB159
Applications
IHC; WB; IF
Application Notes
IHC: 1:500-1:1000
WB: 1 µg/ml
IF: 2-10 µg/ml
Relevant Diseases
Alzheimer's Disease; Huntington's Disease; Parkinson's Disease; Amyotrophic Lateral Sclerosis
Form
Liquid
Formulation
PBS, pH 7.2, 40% glycerol
Preservatives
0.02% Sodium azide
Concentration
1 mg/ml
Purification
Protein A purified
Shipping
Gel Pack
Storage
Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling Advice
The antibody solution should be gently mixed before use.
Research Use Only
For research use only
Target
NSD2
Official Name
NSD2
Full Name
Nuclear Receptor Binding SET Domain Protein 2
Alternative Names
Nuclear Receptor Binding SET Domain Protein 2; Nuclear SET Domain-Containing Protein 2; Wolf-Hirschhorn Syndrome Candidate 1; EC 2.1.1.43; WHSC1; MMSET; TRX5; Multiple Myeloma SET Domain Containing Protein Type III; Probable Histone-Lysine N-Methyltransferase NSD2; Multiple Myeloma SET Domain Containing Protein; Multiple Myeloma SET Domain-Containing Protein
Gene ID
7468(Human); 107823(Mouse)
Uniprot ID
O96028(Human); Q8BVE8(Mouse)
For Research Use Only. Not For Clinical Use.
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