Mouse Anti-GLUL Monoclonal Antibody (CBP2748)

Product Overview

Description

GLUL(Glutamine synthetase) has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner By similarity. Essential for proliferation of fetal skin fibroblasts(PMID:18662667).Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD).Organismal glutamine production is augmented secondary to an increase in the activity of glutamine synthetase in the lung and skeletal muscle.

Expression Host

Mammalian cells

Immunogen

Glutamine Synthetase fusion protein Ag6309

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2748

Applications

IHC; ELISA

Application Notes

IHC : 1:20-1:200

Research Areas

Neuron

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

GLUL

Official Name

GLUL

Full Name

Glutamate-ammonia ligase

Alternative Names

GLNS; GLUL; Glutamate ammonia ligase; Glutamate decarboxylase; Glutamine synthetase; GS; PIG43; PIG59

Gene ID

2752(Human); 14645(Mouse); 24957(Rat)

Uniprot ID

P15104(Human); P15105(Mouse); P09606(Rat)

References

1. Dai, W., Xu, L., Yu, X., Zhang, G., Guo, H., Liu, H.,... & Liu, T. (2020). OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism. Journal of hepatology, 72(5), 909-923.

Publications