Mouse Anti-TGFB1 Monoclonal Antibody (CBP3005)

Product Overview

Description

TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease (CED) which known as progressive diaphyseal dysplasia 1 (DPD1).

Expression Host

Mammalian cells

Immunogen

Human TGF beta 1 protein HZ-1011

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP3005

Applications

Neut; ELISA

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

TGF-β1

Official Name

TGFB1

Full Name

Transforming growth factor, beta 1

Alternative Names

Cartilage-inducing factor;
CED;
Differentiation inhibiting factor;
DPD1;
LAP;
Latency-associated peptide;
Prepro transforming growth factor beta 1;
TGF beta 1;
TGF beta;
TGF beta 1 protein;
TGF-beta 1 protein;

Gene ID

7040(Human); 21803(Mouse); 59086(Rat)

Uniprot ID

P01137(Human); P04202(Mouse); P17246(Rat)

References

1. Liang, J., Chen, C., Liu, H., Liu, X., Li, Z., Hu, J., & Zhao, H. (2018). Gossypol promotes bone formation in ovariectomy-induced osteoporosis through regulating cell apoptosis. BioMed Research International, 2018. 2. Jin, L., Qian, Y., Zhou, J., Dai, L., Cao, C., Zhu, C., & Li, S. (2019). Activated CRH receptors inhibit autophagy by repressing conversion of LC3BI to LC3BII. Cellular signalling, 58, 119-130. 3. Wang, M., Xiong, L., Jiang, L. J., Lu, Y. Z., Liu, F., Song, L. J.,... & Ma, W. L. (2019). miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7. EBioMedicine, 41, 670-682.

Publications