Mouse Anti-CD95 Monoclonal Antibody (CBP4237)

[CAT#: NAB210101LS]

Anti-CD95 Monoclonal Antibody [Biotin]

Host Species:: Mouse

Species Reactivity:: Human; African green monkey; Baboon; Capuchin Monkey; Chimpanzee; Common Marmoset; Cotton-topped Tamarin; Cynomolgus; Porcinetailed Macaque; Rhesus; Sooty Mangabey

Applications:: FC

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Product Overview

Description

CD95 is a 45 kD single chain type I glycoprotein also known as Fas, APO-1, and TNFRSF6. It is a member of the TNF receptor superfamily. CD95 is expressed on T and B lymphocytes, monocytes, neutrophils, and fibroblasts. CD95 expression is upregulated by activation. The extracellular region of CD95 binds to CD178 (Fas ligand). CD178 binding to CD95 induces apoptosis and has been shown to play a role in the maintenance of peripheral tolerance.

Immunogen

CD95 transfected L cells

Species Reactivity

Human; African green monkey; Baboon; Capuchin Monkey; Chimpanzee; Common Marmoset; Cotton-topped Tamarin; Cynomolgus; Porcinetailed Macaque; Rhesus; Sooty Mangabey

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP4237

Applications

Application Notes

FCM (≤0.5 µg per 106 cells in 100 µl volume or 100 µl of whole blood)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Biotin

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD95

Official Name

FAS

Full Name

Fas cell surface death receptor

Alternative Names

CD95; Apoptosis-mediating surface antigen FAS; FAS1; Tumor necrosis factor receptor superfamily member 6; ALPS1A; APT1; FASTM; CD antigen CD95; APO-1; TNFRSF6; FASLG receptor; Apo-1 antigen