NoGeneST™ Anti-PDGF-B Aptamer, aPDGF-B aptamer-1 sodium

Name: NoGeneST™ Anti-PDGF-B Aptamer, aPDGF-B aptamer-1 sodium
SKU: NRYF-0625-HZ44
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ44]

A pegylated DNA aptamer that inhibits Platelet-Derived Growth Factor B (PDGF-B), functioning as an anti-angiogenic agent.

Target:: PDGF-B

Type:: DNA

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Product Overview

Description

This is a 34-base pegylated DNA aptamer that acts as a potent and specific antagonist of Platelet-Derived Growth Factor B (PDGF-B). By binding to PDGF-B, it disrupts the signaling pathway responsible for recruiting pericytes to stabilize nascent blood vessels. This action leads to the regression of tumor vasculature, making the aptamer a promising agent for anti-angiogenic cancer therapy.

Type

DNA

Properties

Size

1 mg; 5 mg; 10 mg

Appearance

Supplied as a lyophilized white to off-white solid.

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

PDGF-B

Full Name

Platelet-Derived Growth Factor B

Alternative Names

PDGF-2; c-sis

Gene ID

5155

Uniprot ID

P01127

Target Overview

Platelet-Derived Growth Factor B (PDGF-B) is a key member of the PDGF family of growth factors and a potent mitogen for cells of mesenchymal origin. By signaling through its receptor, PDGFRβ, it plays a critical role in angiogenesis (the formation of new blood vessels). Specifically, it is responsible for the recruitment of pericytes, which are mural cells that wrap around and stabilize newly forming vessels. This PDGF-B-mediated signaling pathway is often exploited by tumors to develop a robust blood supply, making it a prime target for anti-angiogenic therapies.

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