Aβ shRNA Plasmid Expression Vector Set

Name: Aβ shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY326
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY326]

Target:: Aβ

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Product Overview

Description

A specialized kit designed to suppress the production of Amyloid-beta (Aβ) by targeting the Amyloid Precursor Protein (APP) gene. The set provides three distinct shRNA plasmid vectors aimed at different sequences of the APP mRNA to ensure effective suppression, plus a scrambled shRNA plasmid as a negative control. This tool is critical for researchers to directly study the effects of reduced Aβ load on plaque formation and synaptic toxicity in cellular models of Alzheimer's disease.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

Aβ

Full Name

Amyloid Beta Peptide

Gene ID

351

Uniprot ID

P05067

Target Overview

Amyloid beta (Aβ) is a peptide, typically 36-43 amino acids in length, which is derived from the proteolytic cleavage of the much larger Amyloid Precursor Protein (APP). While Aβ's physiological function is not fully resolved, its role in pathology is central to Alzheimer's disease. The Aβ monomer has a high propensity to misfold and aggregate, forming soluble oligomers, fibrils, and eventually the dense, insoluble amyloid plaques found in the brains of Alzheimer's patients. This aggregation process is considered a primary toxic event that initiates a cascade of neurodegeneration, making Aβ and its various aggregated forms a critical target for therapeutic and diagnostic development.

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