Mouse Anti-PHGDH Monoclonal Antibody (CBP6758)

Description

Neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease and Huntington's disease The result of the gradual loss of neuron structure and function, Causes neuron death. 3-Phosphoglycerate dehydrogenase catalyzes the conversion of 3-phosphoglycerate to 3-phosphohydroxypyruvate, which is an important step in the phosphorylation pathway of L-serine biosynthesis. It is also essential in the synthesis of cysteine and glycine, which is located downstream. This pathway is the only pathway that synthesizes multiple plant pathways in most organisms except plants. Nevertheless, it is still suspected that the phosphorylation pathway involved in PHGDH plays an important role in the synthesis of serine used in plant development signals. Since serine and glycine act as neurotrophic factors in the developing brain, PHGDH has been shown to be highly expressed in glial and astrocytes during nerve development.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP6758

Applications

IHC; WB; IF

Application Notes

IHC: 1:500-1:1000
WB: 1 µg/ml
IF: 2-10 µg/ml

Relevant Diseases

Alzheimer's Disease; Huntington's Disease; Parkinson's Disease; Amyotrophic Lateral Sclerosis

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

PHGDH

Official Name

PHGDH

Full Name

Phosphoglycerate dehydrogenase

Alternative Names

PHGDH; 3-PGDH; 3PGDH; HEL-S-113; NLS; PDG; PGAD; PGD; PGDH; PHGDHD; SERA; NLS1; Phosphoglycerate dehydrogenase

Gene ID

26227(Human)

Uniprot ID

O43175(Human)