NoGeneST™ Anti-APOE4 Aptamer, aAPOE4 aptamer

Name: NoGeneST™ Anti-APOE4 Aptamer, aAPOE4 aptamer
SKU: NRYF-0625-HZ73
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ73]

Aptamers engineered to selectively recognize the Apolipoprotein E4 isoform, a key protein implicated in neurodegenerative pathology.

Target:: APOE4

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Product Overview

Species

Human

Relevant Diseases

Alzheimer's Disease

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

APOE4

Full Name

Apolipoprotein E4 Isoform

Alternative Names

Apolipoprotein E

Gene ID

348

Uniprot ID

P02649

Target Overview

Apolipoprotein E (APOE) is a central protein in lipid metabolism, primarily responsible for transporting cholesterol and other fats. There are three major versions (alleles) of the APOE gene: APOE2, APOE3, and APOE4. The APOE4 isoform is the single most significant genetic risk factor for developing late-onset Alzheimer's disease. Compared to the more common APOE3 form, the APOE4 protein is associated with increased aggregation of amyloid-beta plaques and the formation of tau tangles, both of which are hallmarks of Alzheimer's pathology. This makes the APOE4 isoform a critical target for diagnostic and therapeutic research.

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