NoGeneST™ Anti-R2 Aptamer, aR2 aptamer-1 sodium

Name: NoGeneST™ Anti-R2 Aptamer, aR2 aptamer-1 sodium
SKU: NRYF-0625-HZ23
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ23]

An aptamer targeting ribonucleotide reductase R2 mDNA to inhibit cancer cell proliferation.

Target:: R2

Type:: DNA

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Product Overview

Description

This is a 20-base, phosphorothioate-modified oligonucleotide designed to be complementary to the messenger DNA (mDNA) of the R2 subunit of human ribonucleotide reductase. By specifically binding to its target mDNA, it prevents the synthesis of the R2 protein. This down-regulation inhibits the overall activity of ribonucleotide reductase, a crucial enzyme for DNA synthesis, thereby suppressing tumor growth.

Type

DNA

Properties

Size

1 mg; 5 mg; 10 mg

Appearance

Supplied as a lyophilized white to off-white solid.

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

Full Name

Ribonucleoside-diphosphate reductase subunit M2

Alternative Names

Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit

Gene ID

6241

Uniprot ID

P31350

Target Overview

Ribonucleotide Reductase R2 (RRM2) is the small, regulatory subunit of the enzyme Ribonucleotide Reductase (RNR). The RNR enzyme complex is absolutely essential for de novo DNA synthesis, as it catalyzes the rate-limiting step of converting ribonucleotides into deoxyribonucleotides-the building blocks of DNA. The expression of the R2 subunit is tightly controlled and peaks during the S-phase of the cell cycle to facilitate DNA replication. Because of its critical role in cell proliferation, RRM2 is frequently overexpressed in cancer cells, making it a well-established target for anticancer therapies.

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