NoGeneST™ Anti-Thrombin Aptamer, aThrombin aptamer-1

Name: NoGeneST™ Anti-Thrombin Aptamer, aThrombin aptamer-1
SKU: NRYF-0625-HZ17
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ17]

A 15-base DNA aptamer that specifically binds and inhibits the enzyme thrombin, functioning as a potent anticoagulant.

Target:: Thrombin

Type:: DNA

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Product Overview

Description

This is a compact, single-stranded DNA aptamer composed of 15 deoxynucleotides that folds into a stable G-quadruplex secondary structure. This well-defined conformation enables it to bind with high affinity and specificity to the key coagulation enzyme, thrombin. By occupying the active site or an allosteric site, the aptamer directly blocks thrombin's proteolytic function, thereby preventing the conversion of fibrinogen into fibrin, which is the final and essential step in blood clot formation.

Type

DNA

Properties

Size

1 mg; 5 mg; 10 mg

Appearance

Supplied as a lyophilized white to off-white solid.

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

Thrombin

Alternative Names

Coagulation factor II

Gene ID

2147

Uniprot ID

P00734

Target Overview

Thrombin is the central effector serine protease of the blood coagulation cascade. It is generated from its inactive zymogen, prothrombin, during the final steps of the cascade. Thrombin's primary role is to convert soluble fibrinogen into insoluble fibrin strands, which form the meshwork of a blood clot. Beyond this, it is a powerful prothrombotic agent that amplifies its own production by activating other coagulation factors (V, VIII, XI) and platelets. Due to its pivotal and multifunctional role in both hemostasis and pathological thrombosis, thrombin is a principal target for many anticoagulant therapies.

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