DISC1 shRNA Plasmid Expression Vector Set

Name: DISC1 shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY366
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY366]

Target:: DISC1

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Product Overview

Description

A comprehensive kit for the targeted knockdown of the Disrupted in Schizophrenia 1 (DISC1) gene, a significant risk factor for major psychiatric illnesses. The set provides three validated shRNA plasmid vectors targeting different DISC1 sequences, along with a non-targeting scrambled shRNA plasmid as a negative control. It is a key tool for studying DISC1's role in neurodevelopment and synaptic function.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

DISC1

Full Name

Glutamate Receptor Ionotropic, NMDA 2A

Gene ID

2903

Uniprot ID

Q12879

Target Overview

GRIN2A is a gene that encodes the GluN2A subunit of the NMDA (N-methyl-D-aspartate) receptor. NMDA receptors are glutamate-gated ion channels crucial for excitatory neurotransmission in the brain. They are essential for synaptic plasticity, a fundamental process that underlies learning and memory. The specific subunit composition of the NMDA receptor, including the presence of GluN2A, dictates its functional properties, such as its gating kinetics and pharmacology. Mutations in the GRIN2A gene are a significant cause of a spectrum of neurodevelopmental disorders, including epilepsy with speech impairment and intellectual disability.

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