Creative Biolabs

Mouse Anti-USP46 Monoclonal Antibody (AB146)

[CAT#: NAB2007FY1701]

Amyotrophic Lateral Sclerosis,
Parkinson's, Alzheimer's and Huntington's diseases

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB; IF

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Description
Neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease and Huntington's disease The result of the gradual loss of neuron structure and function, Causes neuron death. Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009]
Epitope
Binds to an located within the peptide sequence TNETRCLNCE
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2b
Clone Number
AB146
Applications
WB; IF
Application Notes
WB: 1 µg/ml
IF: 2-10 µg/ml
Relevant Diseases
Alzheimer's Disease; Huntington's Disease; Parkinson's Disease; Amyotrophic Lateral Sclerosis
Form
Liquid
Formulation
PBS, pH 7.2, 40% glycerol
Preservatives
0.02% Sodium azide
Concentration
1 mg/ml
Purification
Protein A purified
Shipping
Gel Pack
Storage
Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling Advice
The antibody solution should be gently mixed before use.
Research Use Only
For research use only
Target
USP46
Official Name
USP46
Full Name
Ubiquitin Specific Peptidase 46
Alternative Names
Ubiquitin Specific Peptidase 46; Ubiquitin-Specific-Processing Protease 46; Ubiquitin Specific Protease 46; Deubiquitinating Enzyme 46; Ubiquitin Thioesterase 46; EC 3.4.19.12; EC 3.1.2.15
Gene ID
64854(Human)
Uniprot ID
P62068(Human)
For Research Use Only. Not For Clinical Use.
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