NeuroMab™ Anti-PRNP BBB Shuttle Antibody,Clone NR2691P

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG

Clone Number

NR2691P

Applications

IP; WB; ELISA; Inhib; In Vitro

Relevant Diseases

Creutzfeldt-Jakob Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

PRNP

Official Name

PRNP

Full Name

prion protein

Alternative Names

PRNP; ASCR; AltPrP; CD230; CJD; GSS; KURU; PRIP; PrP; PrP27-30; PrP33-35C; PrPc; p27-30; prion protein

Product Pictures

Figure 1. Western blot of normal bovine brain homogenate and recombinant bovine PrP. mAb 6H4 and 34C9 recognize bovine PrP and rbPrP, whereas may 15B3 recognizes only rbPrP Recombinant rbPrP runs lower and more acutely than PrP from brain homogenate because it is not glycosylated.

Figure 2 Conformation-sensitive ELIFA of brain homogenates of BSE diseased and normal bovines under different denaturation states. Stained with monoclonal antibody 15B3. In its native state, mAB 15B3 only stains bovine PrPSc, but not PrPC.

Publications