NeuroMab™ Anti-PRNP BBB Shuttle Antibody, Clone 15B3
[CAT#: NRZP-1022-ZP3588]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IP; WB; ELISA; Inhib; In Vitro
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
Product Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG
Clone Number
15B3
Applications
IP; WB; ELISA; Inhib; In Vitro
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
PRNP
Official Name
PRNP
Full Name
prion protein
Alternative Names
PRNP; ASCR; AltPrP; CD230; CJD; GSS; KURU; PRIP; PrP; PrP27-30; PrP33-35C; PrPc; p27-30; prion protein
Product Pictures
WB
Figure 1. Western blot of normal bovine brain homogenate and recombinant bovine PrP. mAb 6H4 and 34C9 recognize bovine PrP and rbPrP, whereas may 15B3 recognizes only rbPrP Recombinant rbPrP runs lower and more acutely than PrP from brain homogenate because it is not glycosylated.
WB
Figure 2 Conformation-sensitive ELIFA of brain homogenates of BSE diseased and normal bovines under different denaturation states. Stained with monoclonal antibody 15B3. In its native state, mAB 15B3 only stains bovine PrPSc, but not PrPC.
Neural Antibodies
Biomaterials
Neural Genes
For Research Use Only. Not For Clinical Use.
