Mouse Anti-Human TMEM119 Monoclonal Antibody (CBP2255)

Product Overview

Description

Microglia are the resident parenchymal myeloid cells of the CNS, and play an important role in development, homeostasis, disease, and injury. TMEM119 is a transmembrane protein and was identified as a microglia-specific marker in both mouse and human CNS. Moreover, TMEM119 immunoreactivity has been exclusively detected on a subset of Iba1(+) CD68(+) microglia with ramified and amoeboid morphologies in the brains of neurodegenerative diseases. TMEM119 also plays an important role in bone formation and normal bone mineralization. It promotes the differentiation of myoblasts into osteoblasts. and it may induce the commitment and differentiation of myoblasts into osteoblasts. TMEM119 is also essential for normal spermatogenesis and late testicular differentiation.

Immunogen

Recombinant human TMEM119 protein (extracellular domain)

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP2255

Applications

FC; WB; ICC

Application Notes

FCM (≤ 0.6 - 5.0 µg/ml); WB (1.0-5.0 µg/mL); WB (2.0-5.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.05% sodium azide

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

TMEM119

Official Name

TMEM119

Full Name

Transmembrane protein 119

Alternative Names

Transmembrane protein 119

References

1. Bennett ML, et al. 2016. Proc Natl Acad Sci U S A. 113
2. Satoh J, et al. 2016. Neuropathology. 36:39-49
3. Kawao N and Kaji H. 2015. J Cell Biochem. 116:687
4. Zrzavy T, et al. 2017. Brain. 140:1900-1913

Publications