Mouse Anti-Human NG2 Monoclonal Antibody (CBP2347)

Product Overview

Description

CSPG4, best known as neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that is frequently used as a marker for oligodendrocyte progenitor cells. NG2 plays an important role in cell proliferation and migration. It also stabilizes cell-substratum interactions during early events in melanoma cell invasion on the endothelial basement membranes. Missense mutations in NG2 are segregated in familial forms of schizophrenia, implicating its role in neurodevelopmental disorders. Product Details

Immunogen

Endothelial cell line TME-3H3

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP2347

Applications

Application Notes

WB (5.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

NG2

Official Name

CSPG4

Full Name

Chondroitin sulfate proteoglycan 4

Alternative Names

CSPG4; HMW-MAA; MCSP; MCSPG; MEL-CSPG; MSK16; NG2; chondroitin sulfate proteoglycan 4; CSPG4A

Gene ID

1464(Human)

Uniprot ID

Q6UVK1(Human)

References

1. Schäfer MKE and Tegeder I. 2018. Matrix Biol. 68-69:571.
2. Birey F, et al. 2017. Curr Opin Neurobiol. 47:93.
3. Song FE, et al. 2017. CNS Neurosci Ther. 23(7):547

Publications