Mouse Anti-CD289 Monoclonal Antibody (CBP2579)

Product Overview

Description

Mouse anti-human CD289 antibody, recognizes human, canine and murine TLR9, also known as CD289. TLR9 is a member of the Toll-like receptor (TLR) family and acts as a receptor for bacterial DNA (CpG-DNA), playing an important role in pathogen recognition and innate immune activation. TLRs are expressed on the cell surface and endocytic compartments, and recognize pathogen-associated molecular patterns (PAMP) expressed on pathogens. They also initiate cell signaling to induce the production of cytokines necessary for innate immunity and subsequent adaptive immunity.

Immunogen

Fusion protein of human TLR9 (amino acids 1-815).

Species Reactivity

Human; Mouse; Dog

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP2579

Applications

FC; IHC-Fr; WB; IHC-P

Application Notes

FC: 1/10-1/50

Relevant Diseases

Alzheimer's Disease; Neurodegenerative Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.09% Sodium Azide, 1% BSA

Preservatives

YES

Concentration

0.1 mg/ml

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

TLR9

Official Name

TLR9

Full Name

TLR9 Gene(Protein Coding) Toll Like Receptor 9

Alternative Names

Toll Like Receptor 9; Toll-Like Receptor 9; CD289 Antigen; CD289;

Gene ID

54106(Human); 81897(Mouse); 338457(Rat)

Uniprot ID

Q9NR96(Human); Q9EQU3(Mouse)

References

1. Ahmad-Nejad, P. et al. (2002) Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments.
2. Batsford, S. et al. (2011) Protein level expression of Toll-like receptors 2, 4 and 9 in renal disease.
3. Maiolini, A. et al. (2012) Toll-like receptors 4 and 9 are responsible for the maintenance of the inflammatory reaction in canine steroid-responsive meningitis-arteritis, a large animal model for neutrophilic meningitis.

Publications