Mouse Anti-DCTN2 Monoclonal Antibody (CBP2652)

[CAT#: NAB20101726CR]

Mouse Monoclonal (2B9A5) to DCTN2

Host Species:: Mouse

Species Reactivity:: Human; Mouse

Applications:: IHC; WB; ELISA

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Product Overview

Description

Dynamitin is a 50 kDa protein containing a calmodulin binding domain, a putative ATPase domain and MacMARCKS-binding domain. This protein is a part of the dynactin complex believed to link the dynactin complex to membrane compartments. Its functions are tightly associated with dynein motor protein, thus extend to vesicle trafficking and membrane integrity. Dynamitin was named so because its overexpression causes dynactin complex which contains 10 subunits, to disassemble. Its N terminal 58 amino acid is for MacMARCKS binding and residues 59-83 is responsible for calmodulin binding.

Expression Host

Mammalian cells

Immunogen

Dynamitin (1-401 AA) fusion protein Ag1902

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG3

Clone Number

CBP2652

Applications

IHC; WB; ELISA

Application Notes

IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Metabolism

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1500 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

DCTN2

Official Name

DCTN2

Full Name

Dynamitin 2

Alternative Names

DCTN2; dynactin 2; dynactin 2 (p50); Dynactin subunit 2; Dynamitin

Gene ID

10540(Human); 69654(Mouse); 299850(Rat)

Uniprot ID

Q13561(Human); Q99KJ8(Mouse); Q6AYH5(Rat)

References

1. Wu, C. H., Zong, Q., Du, A. L., Zhang, W., Yao, H. C., Yu, X. Q., & Wang, Y. F. (2016). Knockdown of Dynamitin in testes significantly decreased male fertility in Drosophila melanogaster. Developmental biology, 420(1), 79-89.

Publications